Ebina Toshiaki, Tochihara Shiori, Okazaki Mai, Koike Kazuyo, Tsuto Yuko, Tayama Megumi, Takanami Yukiko, Hirose Haruka, Horii Mutsuo, Okada Kozo, Matsuzawa Yasushi, Maejima Nobuhiko, Iwahashi Noriaki, Hibi Kiyoshi, Kosuge Masami, Tamura Kouichi, Kimura Kazuo
Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.
Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.
Heart Vessels. 2022 Mar;37(3):392-399. doi: 10.1007/s00380-021-01936-6. Epub 2021 Sep 13.
The complete blood cell count is one of the most frequently ordered laboratory tests, and many parameters, including red blood cell distribution width (RDW) and mean platelet volume (MPV), are available. The purpose of this study was to investigate the usefulness of the combination of RDW and MPV in patients with ST-segment elevation myocardial infarction (STEMI). Patients with STEMI who underwent primary percutaneous coronary intervention were retrospectively enrolled (n = 229). The association between RDW as well as MPV and cardiovascular events was investigated. The median age was 67 years, and males made up 85% of the sample. Median RDW was 13.6%, and median MPV was 8.2 fL. During a median follow-up period of 528 days (IQR 331.5-920.5), 41 patients died or experienced major adverse cardiac and cerebrovascular events (MACCEs). Patients with RDW ≧ 13.7% had more deaths or MACCEs with marginal significance (p = 0.0799). Patients with MPV ≧ 8.3 fL had significantly more deaths or MACCEs (p = 0.0283). Patients with RDW ≧ 13.7% and MPV ≧ 8.3 fL had significantly more deaths or MACCEs (p = 0.0185). MPV was significantly associated with death or adverse events in patients with STEMI who were treated with primary PCI. RDW had only a weak association with death or adverse events. The results of the combination of MPV and RDW were similar to those of MPV.
全血细胞计数是最常进行的实验室检查之一，可获得许多参数，包括红细胞分布宽度（RDW）和平均血小板体积（MPV）。本研究的目的是探讨RDW和MPV联合检测在ST段抬高型心肌梗死（STEMI）患者中的应用价值。回顾性纳入了接受直接经皮冠状动脉介入治疗的STEMI患者（n = 229）。研究了RDW以及MPV与心血管事件之间的关联。中位年龄为67岁，男性占样本的85%。中位RDW为13.6%，中位MPV为8.2 fL。在中位随访期528天（IQR 331.5 - 920.5）内，41例患者死亡或发生主要不良心脑血管事件（MACCE）。RDW≥13.7%的患者死亡或发生MACCE的情况更多，具有边缘显著性（p = 0.0799）。MPV≥8.3 fL的患者死亡或发生MACCE的情况显著更多（p = 0.0283）。RDW≥13.7%且MPV≥8.3 fL的患者死亡或发生MACCE的情况显著更多（p = 0.0185）。在接受直接PCI治疗的STEMI患者中，MPV与死亡或不良事件显著相关。RDW与死亡或不良事件仅有微弱关联。MPV和RDW联合检测的结果与MPV单独检测的结果相似。
