Hospital Regional Docente de Trujillo, Trujillo, Perú; Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad César Vallejo, Trujillo, Perú. Dirección: Mz A Lote 1M, Urbanización Los Portales del Golf, Víctor Larco Herrera, Trujillo, La Libertad, Perú 13009. Email:
Hospital Regional Docente de Trujillo, Trujillo, Perú; Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad César Vallejo, Trujillo, Perú. ORCID: 0000-0002-6509-4453.
Medwave. 2021 Aug 30;21(7):e8454. doi: 10.5867/medwave.2021.07.8454.
COVID-19 disease can affect women at any stage of pregnancy, and newborns could become infected with SARS-CoV-2 through vertical or horizontal transmission.
To determine clinical and epidemiological characteristics of mothers with COVID-19, associated neonatal outcomes, and to evaluate SARS-CoV-2 vertical transmission.
We conducted an observational, descriptive, cross-sectional study. We included all mothers with positive serology for SARS-CoV-2 and their newborns at the Hospital Regional Docente de Trujillo from April 18 to September 30, 2020. Variables were collected from the medical records, and descriptive statistics were used for the analysis.
A total of 647 mothers and 656 neonates were enrolled. Of all live births, 85.3% and 14.7% were term and preterm neonates, respectively. We found 1.7% (11/656) of newborns with positive RT-PCR for SARS-CoV-2; and that 27.3% (3/11) of these neonates required hospitalization. Neonatal mortality was 4/656 (0.6%), and no case was attributed to COVID-19. Of all mothers affected with COVID-19, 95.7% were asymptomatic, and 4.3% presented clinical symptoms attributed to COVID-19, most of which were mild. The most frequent obstetric complications were preeclampsia-eclampsia, prelabour rupture of membranes, and acute fetal distress. All the mothers were discharged.
We found 1.7% of newborns with positive RT-PCR test for SARS-CoV-2; and that 20.1% of these neonates were hospitalized. The most frequent morbidity was neonatal sepsis and prematurity. The infection was mild among newborns, showing a 0.6% overall mortality, with no cases attributed to COVID-19. We found that only 5% of mothers presented symptoms, most of which were mild to moderate symptoms. There was no record of maternal mortality in this study group. It is not possible to conclude whether vertical transmission or intrapartum-acquired infection is responsible for neonatal COVID-19 infections.
COVID-19 疾病可影响妊娠各阶段的女性，新生儿可通过垂直或水平传播感染 SARS-CoV-2。
确定 COVID-19 母亲的临床和流行病学特征、相关新生儿结局，并评估 SARS-CoV-2 的垂直传播。
我们进行了一项观察性、描述性、横断面研究。我们纳入了 2020 年 4 月 18 日至 9 月 30 日在特鲁希略地区教学医院就诊的所有 SARS-CoV-2 血清学阳性的母亲及其新生儿。从病历中收集变量，并进行描述性统计分析。
共纳入 647 名母亲和 656 名新生儿。所有活产儿中，足月产儿和早产儿分别占 85.3%和 14.7%。我们发现 1.7%（11/656）的新生儿 SARS-CoV-2 RT-PCR 阳性；其中 27.3%（11/11）需要住院治疗。新生儿死亡率为 4/656（0.6%），无病例归因于 COVID-19。所有患有 COVID-19 的母亲中，95.7%无症状，4.3%出现 COVID-19 相关临床症状，多数为轻症。最常见的产科并发症是子痫前期-子痫、胎膜早破和急性胎儿窘迫。所有母亲均出院。
我们发现 1.7%的新生儿 SARS-CoV-2 RT-PCR 检测阳性；其中 20.1%的新生儿住院。最常见的发病率是新生儿败血症和早产。新生儿感染症状较轻，总死亡率为 0.6%，无病例归因于 COVID-19。我们发现只有 5%的母亲出现症状，多数为轻至中度症状。本研究组无孕产妇死亡记录。无法确定新生儿 COVID-19 感染是垂直传播还是分娩时获得性感染所致。
