Department of Chemistry, University of Kurdistan, P.O. Box 416, Sanandaj, Iran.
Nanotechnology Research Center, University of Kurdistan, P.O. Box 416, Sanandaj, Iran.
J Fluoresc. 2021 Nov;31(6):1805-1813. doi: 10.1007/s10895-021-02805-1. Epub 2021 Sep 14.
This work focuses on the synthesis of novel modified core-shell CdTe/CdS quantum dots (QDs) and develops as a fluorescence sensor for glucose determination. The (E)-2,2'-(4,4'-dioxo-2,2'-dithioxo-2H,2'H-[5,5'-bithiazolylidene]-3,3'(4H,4'H)-diyl)bis(3- mercaptopropanoic acid) (DTM) as a new derivative of thiazolidine was synthesized and characterized and used to surface-modification of CdTe/CdS QDs. DTM-capped CdTe/CdS QDs used to immobilization of glucose oxidase (GOD). The intensity fluorescence emission of the CdSe/CdS-DTM/GOD is highly sensitive to the concentration of HO as a byproduct of the catalytic oxidation of glucose. The experimental results showed that the quenched fluorescence was proportional to the glucose concentration within the range of 10 nM-0.32 μM under optimized experimental conditions. The limit of detection of this system was found to be 4.3 nM. Compared with most of the existing methods, this newly developed system possesses many advantages, including simplicity, low cost, and good sensitivity.
这项工作专注于合成新型修饰核壳型 CdTe/CdS 量子点（QDs），并将其开发为用于葡萄糖测定的荧光传感器。（E）-2,2'-(4,4'-二氧代-2,2'-二硫代-2H,2'H-[5,5'-联噻唑基亚甲基]-3,3'(4H,4'H)-二基)双(3-巯基丙酸)（DTM）作为噻唑烷的一种新衍生物被合成并进行了表征，并用于 CdTe/CdS QDs 的表面修饰。DTM 封端的 CdTe/CdS QDs 用于固定葡萄糖氧化酶（GOD）。CdSe/CdS-DTM/GOD 的荧光发射强度对作为葡萄糖催化氧化副产物的 HO 的浓度非常敏感。实验结果表明，在优化的实验条件下，该体系的猝灭荧光与 10 nM-0.32 μM 范围内的葡萄糖浓度呈正比。该系统的检测限被发现为 4.3 nM。与大多数现有方法相比，这个新开发的系统具有许多优点，包括简单、低成本和良好的灵敏度。
