Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Kargar Ave., Tehran, Iran.
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Clin Exp Med. 2022 Aug;22(3):427-438. doi: 10.1007/s10238-021-00758-0. Epub 2021 Sep 14.
Complement dysfunction results in impaired ability in clearing apoptotic cell debris that may stimulate autoantibody production in systemic lupus erythematosus (SLE). Herein, we provided a comprehensive search to find and meta-analyze any complement gene polymorphisms associated with SLE. The ITGAM, C1q, and MBL gene polymorphisms were included in this meta-analysis to reveal the exact association with SLE risk. Electronic databases, including Scopus, PubMed, and Google Scholar, were searched to find studies investigating the ITGAM, C1q, and MBL gene polymorphisms and SLE risk in different populations. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were used to analyze the association between ITGAM, C1q, and MBL gene polymorphisms and susceptibility to SLE. According to inclusion criteria, a total of 24 studies, comprising 4 studies for C1QA rs292001, 5 studies for C1QA rs172378, 9 studies for ITGAM rs1143679, 8 studies for MBL rs1800450, 3 studies for MBL2 rs1800451, and 3 studies for MBL2 rs5030737, were included in the final meta-analysis. A significant positive association was found between rs1143679 and SLE risk, while rs1800451 significantly associated with decreased SLE susceptibility. In summary, ITGAM gene rs1143679 SNP and MBL gene rs1800451 SNP were positively and negatively associated with SLE risk, respectively.
补体功能障碍导致清除凋亡细胞碎片的能力受损，这可能会刺激系统性红斑狼疮（SLE）中的自身抗体产生。在此，我们进行了全面检索，以寻找并荟萃分析与 SLE 相关的任何补体基因多态性。本荟萃分析纳入了 ITGAM、C1q 和 MBL 基因多态性，以揭示其与 SLE 风险的确切关联。我们检索了 Scopus、PubMed 和 Google Scholar 等电子数据库，以查找研究 ITGAM、C1q 和 MBL 基因多态性与不同人群中 SLE 风险的研究。使用合并优势比（OR）及其相应的 95%置信区间（CI）来分析 ITGAM、C1q 和 MBL 基因多态性与 SLE 易感性之间的关联。根据纳入标准，共有 24 项研究纳入最终荟萃分析，其中包括 4 项 C1QA rs292001 研究、5 项 C1QA rs172378 研究、9 项 ITGAM rs1143679 研究、8 项 MBL rs1800450 研究、3 项 MBL2 rs1800451 研究和 3 项 MBL2 rs5030737 研究。rs1143679 与 SLE 风险之间存在显著的正相关，而 rs1800451 与 SLE 易感性降低显著相关。总之，ITGAM 基因 rs1143679 SNP 和 MBL 基因 rs1800451 SNP 分别与 SLE 风险呈正相关和负相关。
