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[继发性甲状旁腺功能亢进透析患者围手术期高钾血症的预测]

[Prediction of perioperative hyperkalemia in dialysis patients with secondary hyperparathyroidism].

作者信息

Ou W J, Kang J, Liu S X, Li S J, Chen S H, Zhang S Y, Ge P J

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510030, China.

Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510030, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Aug 7;56(8):854-857. doi: 10.3760/cma.j.cn115330-20201216-00924.

Abstract

To explore the influencing factors for serum potassium >4.4 mmol/L in the morning of parathyroidectomy in hemodialysis patients with secondary hyperparathyroidism (SHPT). The clinical data of 72 patients with SHPT who received regular hemodialysis and underwent parathyroidectomy in Guangdong Provincial People's Hospital from January 2012 to December 2018 were analyzed retrospectively. There were 37 males and 35 females, aged from 25 to 69 years, and the dialysis timespan was from 0.5 to 11 years. The levels of parathyroid hormone, serum potassium and serum calcium before hemodialysis were examined one day before operation, and hemodialysis time and dewatering volume after hemodialysis without heparin were recorded, and also the level of serum potassium in the morning of parathyroidectomy was detected. The occurrences of hyperkalemia during and after operation were studied. The factors related to hyperkalemia in the morning of parathyroidectomy were evaluated by Pearson or Spearman correlation analysis, and the cut-off values of risk factors were calculated by receiver operating characteristic (ROC) curve. Serum potassium >4.4 mmol/L in the morning of parathyroidectomy existed in 23 of 72 patients. Correlation analysis showed that serum potassium one day before operation ((4.93±0.56)mmol/L, 0.656, 0.001) and dehydration volume ((2.37±0.75)L, 0.261, 0.027) were positively correlated with serum potassium in the morning of parathyroidectomy((4.16±0.54)mmol/L). Serum potassium before hemodialysis one day before operation was a main predictor for serum potassium in the morning of parathyroidectomy (AUC=0.791, 0.001). The cut-off value of serum potassium before hemodialysis one day before operation was 5.0 mmol/L. Serum potassium before hemodialysis one day before operation in patients with SHPT can predict serum potassium in the morning of parathyroidectomy, offering imformation for the safety of operation.

摘要

探讨继发性甲状旁腺功能亢进症(SHPT)血液透析患者甲状旁腺切除术前晨血清钾>4.4 mmol/L的影响因素。回顾性分析2012年1月至2018年12月在广东省人民医院接受规律血液透析并进行甲状旁腺切除术的72例SHPT患者的临床资料。其中男性37例,女性35例,年龄2569岁,透析时间0.511年。术前1天检测透析前甲状旁腺激素、血清钾和血清钙水平,记录无肝素血液透析时间及透析后脱水量,并检测甲状旁腺切除术前晨血清钾水平。研究手术中和术后高钾血症的发生情况。采用Pearson或Spearman相关分析评估甲状旁腺切除术前晨高钾血症的相关因素,通过受试者工作特征(ROC)曲线计算危险因素的截断值。72例患者中23例甲状旁腺切除术前晨血清钾>4.4 mmol/L。相关分析显示,术前1天透析前血清钾((4.93±0.56)mmol/L,0.656,0.001)和脱水量((2.37±0.75)L,0.261,0.027)与甲状旁腺切除术前晨血清钾((4.16±0.54)mmol/L)呈正相关。术前1天透析前血清钾是甲状旁腺切除术前晨血清钾的主要预测指标(AUC=0.791,0.001)。术前1天透析前血清钾的截断值为5.0 mmol/L。SHPT患者术前1天透析前血清钾可预测甲状旁腺切除术前晨血清钾,为手术安全提供参考。

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