Selection for resistance to aflatoxin in chickens.

Two populations of broiler chickens [Athens-Canadian (AC) and a commercial stock] were selected for resistance to aflatoxicosis by dosing chickens in each population with a single oral dose of aflatoxin, which resulted in 40 to 70% mortality. Chickens that did not receive aflatoxin served as the nonselected control groups. Birds surviving the aflatoxin challenge were used as breeders for subsequent generations. Rapid progress was made in the AC population for resistance to aflatoxin, but only moderate progress for this trait was attained in the commercial broiler stock. After five generations of selection in the AC population, LD50 values of 9.42 and 17.05 milligrams aflatoxin per kilogram body weight (BW) were determined for the nonselected and selected lines, respectively. After four generations of selection in the commercial broiler population, LD50 values of 6.05 and 8.02 mg aflatoxin/kg BW were determined for the nonselected and selected lines, respectively. These data demonstrate that genetic progress can be made in chickens, but the amount of progress for resistance to aflatoxin may be influenced by the population.