二芳基甲烷与亚砜亚胺或二苯甲酮亚胺的电化学氧化C(sp)-H/N-H偶联反应
Electrochemical Oxidative C(sp)-H/N-H Coupling of Diarylmethanes with Sulfoximines or Benzophenone Imine.
作者信息
Kong Xianqiang, Tian Yan, Chen Xiaohui, Chen Yiyi, Wang Wei
机构信息
Research Center of Resources and Environment, School of Chemical Engineering and Materials, Changzhou Institute of Technology, Changzhou 213032, China.
Changzhou Vocational Institute of Engineering, Changzhou 213164, China.
出版信息
J Org Chem. 2021 Oct 1;86(19):13610-13617. doi: 10.1021/acs.joc.1c01647. Epub 2021 Sep 15.
Herein, we report an efficient electrochemical method for the synthesis of -alkylated sulfoximines by electrochemical oxidative C(sp)-H/N-H coupling of sulfoximines and diarylmethanes. In addition, we used the same conditions for electrochemical dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent. The reactions showed good functional group tolerance and afforded the corresponding products in moderate to good yields without the use of a stoichiometric oxidant, a metal catalyst, or an activating agent.
在此，我们报道了一种通过亚砜亚胺与二芳基甲烷的电化学氧化C(sp)-H/N-H偶联反应高效合成α-烷基化亚砜亚胺的电化学方法。此外，我们使用相同的条件，以二苯甲酮亚胺作为胺化剂，对二芳基甲烷进行电化学脱氢胺化反应。这些反应表现出良好的官能团耐受性，并且在不使用化学计量的氧化剂、金属催化剂或活化剂的情况下，以中等至良好的产率得到相应的产物。
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