通过钯（II）催化的氧化 Heck 反应和脱氢芳构化在一步序列中从吲哚和环己烯酮合成 -(吲哚-3-基)苯酚。
Synthesis of -(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence.
机构信息
College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
出版信息
Org Lett. 2021 Oct 1;23(19):7467-7471. doi: 10.1021/acs.orglett.1c02679. Epub 2021 Sep 15.
Facile construction of a -(indol-3-yl)phenol framework with a wide substrate scope (a total of 25 compounds) via a palladium(II)-catalyzed oxidative Heck reaction and dehydrogenative aromatization in a one-step sequence is reported. This methodology affords a novel route for the privileged structures that are challenging to access via a direct link between indole and phenol, in a highly efficient and atom-economical manner.
通过钯（II）催化的氧化 Heck 反应和脱氢芳构化的一步序列，报告了具有广泛底物范围（总共 25 种化合物）的 -（吲哚-3-基）苯酚骨架的简便构建。该方法提供了一种通过吲哚和苯酚之间的直接键合难以获得的优势结构的新途径，具有高效和原子经济性。
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