Dunn A J, Hall N R
Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610.
Brain Behav Immun. 1987 Jun;1(2):113-22. doi: 10.1016/0889-1591(87)90014-6.
Injection of thymosin fraction 5 (TF5) or the supernatant fluid from concanavalin A-stimulated rat spleen cells into mice significantly increased plasma concentrations of corticosterone at 1 or 3 h. However, measurement of the concentrations of the catecholamines, norepinephrine and dopamine, the indoleamine, serotonin, and their major metabolites, in prefrontal cortex, parietal cortex, nucleus accumbens, septum, caudate-putamen, hypothalamus, and brain stem did not indicate any statistically significant changes. Nor was there any alteration in splenic norepinephrine content. These data suggest that TF5 and lymphokines do not cause a generalized stress response, but rather a selective activation of the pituitary-adrenal axis, probably by causing release of adrenocorticophic hormone from the pituitary. There was no evidence that the corticotropin-releasing activity of TF5 was related to an effect on hypothalamic biogenic amines. These data are discussed in the light of previous results obtained with lymphokine-containing supernatant fluids.
给小鼠注射胸腺素组分5（TF5）或伴刀豆球蛋白A刺激的大鼠脾细胞的上清液，可在1小时或3小时时显著提高血浆皮质酮浓度。然而，对前额叶皮质、顶叶皮质、伏隔核、隔区、尾状核-壳核、下丘脑和脑干中的儿茶酚胺、去甲肾上腺素和多巴胺、吲哚胺、5-羟色胺及其主要代谢产物浓度的测定，并未显示出任何具有统计学意义的变化。脾去甲肾上腺素含量也没有改变。这些数据表明，TF5和淋巴因子不会引起全身性应激反应，而是可能通过促使垂体释放促肾上腺皮质激素，选择性激活垂体-肾上腺轴。没有证据表明TF5的促肾上腺皮质激素释放活性与对下丘脑生物胺的作用有关。结合先前使用含淋巴因子的上清液获得的结果对这些数据进行了讨论。
