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阿特拉津的致癌性试验:对雄性瑞士白化小鼠进行腹腔注射给药的13个月研究的初步报告。

Carcinogenicity testing of atrazine: preliminary report on a 13-month study on male Swiss albino mice treated by intraperitoneal administration.

作者信息

Donna A, Betta P G, Robutti F, Bellingeri D

机构信息

Department of Pathology, City Hospital, U.S.S.L., Alessandria, Italy.

出版信息

G Ital Med Lav. 1986 May-Jul;8(3-4):119-21.

PMID:3452555
Abstract

A statistically significant increase (p less than 0.001) of lymphomas (4 of plasmacell type and two of histiocytic type) was found in a group of 30 Swiss albino mice which were given intraperitoneally 0.25 cc of a 2 ppm solution of atrazine for 13 times every third day to total administration of 0.26 mg of Atrazine/kg of body weight. Lymphomas arising in two groups of 50 controls was 0 and 1 respectively.

摘要

在一组30只瑞士白化小鼠中,每三天腹腔注射0.25毫升2 ppm的阿特拉津溶液,共注射13次,使每千克体重的阿特拉津总给药量达到0.26毫克。结果发现淋巴瘤的发生率有统计学显著增加(p小于0.001),其中浆细胞型淋巴瘤4例,组织细胞型淋巴瘤2例。两组各50只对照小鼠中出现的淋巴瘤分别为0例和1例。

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