帕金森病患者潜在不合理的抗精神病药和抗胆碱能药物处方。
Potentially inappropriate prescriptions of antipsychotic and anticholinergic drugs in patients with Parkinson's disease.
机构信息
Grupo de Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.
Semillero de investigación en Farmacología Geriátrica, Grupo de Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, 660003, Risaralda, Colombia.
出版信息
Neurodegener Dis Manag. 2021 Oct;11(5):361-371. doi: 10.2217/nmt-2021-0021. Epub 2021 Sep 16.
The objective was to determine the prevalence of the potentially inappropriate antipsychotics and anticholinergics used in patients with Parkinson's disease. A cross-sectional study identified the prescription of antipsychotics, anticholinergics and drugs for the treatment of Parkinson's disease. The anticholinergic burden was evaluated, and quetiapine and clozapine were considered to be adequate antipsychotics. 2965 patients with Parkinson's disease were identified. The presence of psychiatric disorders and other neurological pathologies was associated with a greater probability of receiving potentially inappropriate antipsychotic prescriptions. The presence of greater number of comorbidities was associated with a greater probability of receiving anticholinergics. Older age and associated comorbidities, especially psychiatric and neurological comorbidities, increase the likelihood of patients with Parkinson's disease being prescribed antipsychotics and anticholinergics.
目的在于确定帕金森病患者中使用的潜在不适当抗精神病药和抗胆碱能药物的流行情况。一项横断面研究确定了抗精神病药、抗胆碱能药物和治疗帕金森病的药物的处方。评估了抗胆碱能药物负担，并且将喹硫平和氯氮平视为合适的抗精神病药。确定了 2965 例帕金森病患者。存在精神障碍和其他神经病理学与接受潜在不适当抗精神病药处方的可能性更大相关。合并症数量较多与接受抗胆碱能药物的可能性更大相关。年龄较大和合并症，尤其是精神和神经合并症，增加了帕金森病患者被开具抗精神病药和抗胆碱能药物的可能性。
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