儿童盆腔横纹肌肉瘤（RMS）的计算机断层扫描（CT）特征。

Computed Tomography (CT) Features of Pelvic Rhabdomyosarcoma (RMS) in Children.

机构信息

Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

Department of Orthopaedics, People\'s Hospital of Ju County, Shandong Province, 276500, China.

出版信息

Curr Med Imaging. 2022;18(3):299-304. doi: 10.2174/1573405617666210826160710.

DOI:10.2174/1573405617666210826160710

PMID:34525936

Abstract

BACKGROUND

Currently, there are few literature reports on the CT features of pelvic rhabdomyosarcoma, most of which exist in the form of case reports, and some literature reports have suggested that CT features of pelvic rhabdomyosarcoma lack specificity. This study was designed to investigate the CT features of pelvic RMS in children to provide imaging evidence for clinical diagnosis.

METHODS

We retrospectively reviewed radiographic and clinical data of all paediatric patients with pelvic neoplastic lesions pathologically proven to be malignant in our hospitals from January 2012 through March 2021. The data of the included paediatric patients were divided into two groups according to whether the pathology results indicated RMS. CT features of RMS (n = 37) and non- RMS (n = 91) were compared by two abdominal radiologists.

RESULTS

A total of 9 CT features were statistically significant for the diagnosis of pelvic RMS in children (p < 0.05). The sensitivity (range, 0.64-0.74) and specificity (range, 0.86-0.93) of the CT features showing multinodular fusion, surrounding blood vessels, and heterogeneous progressive centripetal enhancement were both relatively high. The CT features indicating lower than muscle density, necrosis, non-calcification and non-haemorrhage exhibited high specificity (range, 0.86-0.97), but the sensitivity (range, 0.32-0.40) was relatively low, while the sensitivity (range, 0.37-0.46) and specificity (range, 0.75-0.83) of other CT features used for diagnosing pelvic RMS, namely, lobulated and lymphatic metastasis, were both relatively low.

CONCLUSION

Pelvic rhabdomyosarcoma in children has its own specific CT features.

摘要

背景

目前，关于骨盆横纹肌肉瘤的 CT 特征的文献报道较少，大多以病例报告的形式存在，部分文献报道提示骨盆横纹肌肉瘤的 CT 特征缺乏特异性。本研究旨在探讨儿童骨盆 RMS 的 CT 特征，为临床诊断提供影像学依据。

方法

我们回顾性分析了 2012 年 1 月至 2021 年 3 月在我院经病理证实为恶性的骨盆肿瘤患儿的影像学和临床资料。将纳入的患儿资料根据病理结果是否为 RMS 分为两组，由 2 位腹部放射科医生比较 RMS（n = 37）和非 RMS（n = 91）的 CT 特征。

结果

共有 9 项 CT 特征对儿童骨盆 RMS 的诊断具有统计学意义（p < 0.05）。显示多结节融合、周围血管和不均匀性向心性渐进性增强的 CT 特征的灵敏度（范围为 0.64-0.74）和特异性（范围为 0.86-0.93）均较高。CT 特征提示密度低于肌肉、坏死、无钙化和无出血具有较高的特异性（范围为 0.86-0.97），但灵敏度（范围为 0.32-0.40）相对较低，而用于诊断骨盆 RMS 的其他 CT 特征（如分叶状和淋巴转移）的灵敏度（范围为 0.37-0.46）和特异性（范围为 0.75-0.83）均较低。