[大鼠实验性下丘脑性肥胖中的内分泌变化]
[Endocrine changes in experimental hypothalamic obesity in rats].
作者信息
Epshteĭn E V, Bezrukov V V
出版信息
Probl Endokrinol (Mosk). 1978 Jan-Feb;24(1):55-60.
Hypothalamic adiposity in rats developing in bilateral electrolytic damage of the ventromedial hypothalamus is characterized by a marked activation of the insular apparatus of the pancreas, enhanced biosynthesis and secretion of the somatotropin by the hypophysis, reduction of the thyrotropic function of the hypophysis and functional activity of the thyroid gland with a disturbed metabolism of the thyroid hormones in target tissues, unchanged or reduced glucocorticoid function of the adrenal glands, intensified lipogenesis, reduction of the content of cyclic 3',5'-adenosinmonophosphate in a number of organs and tissues.
双侧腹内侧下丘脑发生电解损伤的发育中大鼠的下丘脑性肥胖，其特征为胰腺岛器明显激活、垂体生长激素的生物合成和分泌增强、垂体促甲状腺功能及甲状腺功能活动降低，靶组织中甲状腺激素代谢紊乱、肾上腺糖皮质激素功能无变化或降低、脂肪生成增强、许多器官和组织中3',5'-环磷酸腺苷含量减少。
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