Kawashima Hisashi, Inagaki Natsuko, Nakayama Toshihiro, Morichi Shinichiro, Nishimata Shigeo, Yamanaka Gaku, Kashiwagi Yasuyo
Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Shinjuku-ku, Japan.
Department of Clinical Genetic Center, Tokyo Medical University, Shinjuku-ku, Tokyo Japan.
Glob Pediatr Health. 2021 Sep 7;8:2333794X211044114. doi: 10.1177/2333794X211044114. eCollection 2021.
We investigated 22 cases of patients with myocarditis during respiratory syncytial virus (RSV) infection by a questionnaire survey, and performed a literature search to clarify their characteristics. The age distribution was divided into 2 groups, that is, 1 group comprised of patients younger than 4-years old and the other comprised patients older than 15 years. ECG demonstrated disturbance of the conduction system (AV block) in 7 out of 18 patients (38.8%), myocardial damage (ST-T change) in 9 out of 18 patients (50.0%), and tachycardia in 3 out of 18 patients (16.6%). Echocardiography displayed a robust decrease in left-heart function in 12 out of 14 patients. The outcome was 2 deaths, 1 pacemaker placement, 4 patients with mild sequel. Our data suggest that RSV myocarditis caused by RSV infection can be divided into 3 different pathophysiologies, characterized by disturbance of the conduction system, myocardial damage, and increase of autonomy.
我们通过问卷调查对22例呼吸道合胞病毒（RSV）感染期间患心肌炎的患者进行了调查，并进行文献检索以明确其特征。年龄分布分为2组，即1组为4岁以下患者，另一组为15岁以上患者。心电图显示，18例患者中有7例（38.8%）存在传导系统紊乱（房室传导阻滞），18例患者中有9例（50.0%）存在心肌损伤（ST-T改变），18例患者中有3例（16.6%）存在心动过速。超声心动图显示，14例患者中有12例左心功能显著下降。结果为2例死亡，1例植入起搏器，4例有轻度后遗症。我们的数据表明，由RSV感染引起的RSV心肌炎可分为3种不同的病理生理类型，其特征分别为传导系统紊乱、心肌损伤和自主性增加。
