Wan Jin-Lin, Cui Jian-Feng, Zhong Wei-Qiang, Huang Jing-Mei
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China.
Chem Commun (Camb). 2021 Oct 5;57(79):10242-10245. doi: 10.1039/d1cc03891e.
Iminyl radicals are reactive intermediates that can be used for the construction of various valuable heterocycles. Herein, the electrochemical decarboxylation of α-imino-oxy acids for the generation of iminyl radicals has been accomplished under exogenous-oxidant- and metal-free conditions through the use of BuNBr as a mediator. The resulting iminyl radicals undergo intramolecular cyclization smoothly with the adjacent (hetero)arenes to afford a series of indole-fused polycyclic compounds.
亚胺基自由基是可用于构建各种有价值杂环的反应中间体。在此，通过使用BuNBr作为介质，在无外源氧化剂和无金属的条件下实现了α-亚胺氧基酸的电化学脱羧以生成亚胺基自由基。生成的亚胺基自由基与相邻的（杂）芳烃顺利进行分子内环化，得到一系列吲哚稠合的多环化合物。
