Department of Mechanical and Aerospace Engineering, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Department of Human Kinetics, University of Ottawa, 200 Lees Avenue, Ottawa, ON, K1S 5S9, Canada.
Ann Biomed Eng. 2021 Oct;49(10):2836-2851. doi: 10.1007/s10439-021-02857-1. Epub 2021 Sep 15.
The dynamic response of the human brain subjected to impulsive loading conditions is of fundamental importance to the understanding of traumatic brain injuries. Due to the complexity of such measurements, the existing experimental datasets available to researchers are sparse. However, these measurements are used extensively in the validation of complex finite element models used in the design of protective equipment and the development of injury mitigation strategies. The primary objective of this study was to develop a comprehensive methodology to measure displacement in specific anatomical regions of the brain. A state-of-the-art high-speed cineradiography system was used to capture brain motion in post-mortem human surrogate specimens at a rate of 7500 fps. This paper describes the methodology used to capture these data and presents measurements from these tests. Two-dimensional displacement fields are presented and analyzed based on anatomical regions of the brain. These data demonstrated a multi-modal displacement response in several regions of the brain. The full response of the brain consisted of an elastic superposition of a series of bulk rotations of the brain about its centre of gravity. The displacement field could be linked directly to specific anatomical regions. The methods presented mark an improvement in temporal and spatial resolution of data collection, which has implications for our developing understanding of brain trauma.
人类大脑在受到脉冲加载条件下的动态响应对于理解创伤性脑损伤至关重要。由于此类测量的复杂性，研究人员可获得的现有实验数据集非常有限。然而，这些测量结果广泛用于保护设备设计和损伤缓解策略开发中所使用的复杂有限元模型的验证。本研究的主要目的是开发一种全面的方法来测量大脑特定解剖区域的位移。使用最先进的高速电影射线照相系统以 7500 fps 的速率捕获死后人体替代标本中的大脑运动。本文介绍了用于捕获这些数据的方法，并展示了来自这些测试的测量结果。根据大脑的解剖区域呈现和分析二维位移场。这些数据表明大脑在几个区域表现出多模态位移响应。大脑的完整响应由大脑围绕其重心的一系列整体旋转的弹性叠加组成。位移场可以直接与特定的解剖区域相关联。所提出的方法标志着数据采集的时间和空间分辨率的提高，这对我们不断发展的脑外伤理解具有重要意义。
