人源 Tr1 样细胞的体外 microRNA 和基因表达谱分析提示 miR-92a 和 -125a 在调控 EOMES 和 IL-10R 中的作用。
Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R.
机构信息
Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
Institute for Research in Biomedicine (IRB), Università della Svizzera italiana (USI), Bellinzona, Switzerland.
出版信息
Eur J Immunol. 2021 Dec;51(12):3243-3246. doi: 10.1002/eji.202149315. Epub 2021 Sep 28.
Ex vivo gene expression and miRNA profiling of Eomes Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4 T-cells. Several microRNAs were downregulated in Eomes Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.
体外基因表达和 miRNA 分析显示，Eomes Tr1 样细胞代表了 Th1 细胞和细胞毒性 CD4 T 细胞之间的分化阶段。Eomes Tr1 样细胞中下调了几种 microRNA，这些 microRNA 可能抑制 Tr1 细胞分化。特别是，miR-92a 靶向 Eomes，而 miR-125a 抑制 IFN-g 和 IL-10R 的表达。
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