辅助治疗对可切除胆囊癌失败模式和生存的影响。

Influence of adjuvant therapy on pattern of failure and survival in curatively resected gallbladder carcinoma.

机构信息

Department of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Department of Radiotherapy, Apex Cancer Institute, Apex Hospital, Varanasi, Uttar Pradesh, India.

出版信息

J Cancer Res Ther. 2021 Jul-Sep;17(4):1064-1068. doi: 10.4103/jcrt.JCRT_550_19.

DOI:10.4103/jcrt.JCRT_550_19

PMID:34528565

Abstract

PURPOSE

The study was done to evaluate the role of adjuvant therapy in curatively resected Stage II and III gallbladder carcinoma (GBC).

MATERIALS AND METHODS

This was a retrospective analysis of patients of GBC registered between 2008 and 2017 in outpatient department of a tertiary cancer hospital in India. Patients who had any of the following adjuvant treatment after radical surgery: (a) external beam radiotherapy (RT) alone, (b) chemotherapy (CT) alone, and (c) RT with CT (CRT) were considered for the study.

RESULTS

A total of fifty patients could meet the selection criteria. It was seen that seven patients were treated with RT, 20 with CT, and 23 with CRT. Median follow-up for patients who were alive was 26.7 months. Nineteen patients had locoregional failure while eight had distant failure. Patients treated with CRT had a significantly better mean overall survival compared to those treated with RT or CT (44.0 months, 12.5 months, and 15.1 months, respectively; P = 0.003). Similarly, mean disease-free survival was superior in CRT arm compared to RT and CT arms (43.6 months, 9.6 months, and 12.4 months, respectively; P = 0.002).

CONCLUSIONS

Adjuvant CRT had better survival outcome compared to patients treated with either RT or CT with Stage II and III disease after curative cholecystectomy.

摘要

目的

本研究旨在评估辅助治疗在可切除 II 期和 III 期胆囊癌（GBC）中的作用。

材料和方法

这是对印度一家三级癌症医院门诊部 2008 年至 2017 年间登记的 GBC 患者进行的回顾性分析。在根治性手术后接受以下任何辅助治疗的患者被认为符合研究条件：（a）单纯外照射放疗（RT），（b）单纯化疗（CT），和（c）RT 联合 CT（CRT）。

结果

共有 50 名患者符合选择标准。结果显示，7 名患者接受 RT 治疗，20 名患者接受 CT 治疗，23 名患者接受 CRT 治疗。存活患者的中位随访时间为 26.7 个月。19 名患者发生局部区域复发，8 名患者发生远处转移失败。接受 CRT 治疗的患者的总体生存率明显优于接受 RT 或 CT 治疗的患者（分别为 44.0 个月、12.5 个月和 15.1 个月；P = 0.003）。同样，CRT 组的无病生存率也优于 RT 组和 CT 组（分别为 43.6 个月、9.6 个月和 12.4 个月；P = 0.002）。