Department of Pathology, Maulana Azad Medical College, New Delhi, India.
Department of Otorhinolaryngology And Head And Neck Surgery, Maulana Azad Medical College, New Delhi, India.
J Cancer Res Ther. 2021 Jul-Sep;17(4):1115-1118. doi: 10.4103/jcrt.JCRT_645_19.
Acinic cell carcinoma (ACC) is a malignant salivary gland tumor characterized by tumor cells displaying acinar features. Usually presenting as a slow-growing tumor, ACC, however, may show dedifferentiation to a higher grade including neuroendocrine carcinoma. In addition, ACC may rarely show focal neuroendocrine differentiation without any frank evidence of neuroendocrine carcinoma. We describe such a case of ACC of the parotid gland in a 65-year-old female, which showed neuroendocrine differentiation. The diagnostic clues, immunohistochemistry panel, and prognostic and treatment aspects are also presented.
闰管细胞癌（ACC）是一种恶性涎腺肿瘤，其特征为肿瘤细胞呈现出闰管样特征。通常表现为生长缓慢的肿瘤，但 ACC 可能会向更高级别分化，包括神经内分泌癌。此外，ACC 也可能偶尔出现局灶性神经内分泌分化，而没有任何神经内分泌癌的明确证据。我们描述了一例 65 岁女性的腮腺 ACC，其表现出神经内分泌分化。还介绍了该病例的诊断线索、免疫组织化学标志物以及预后和治疗方面。
