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药物涂层球囊在冠状动脉分叉病变介入治疗中的应用

[Use of drug-coated balloons for interventions on bifurcation lesions of coronary arteries].

作者信息

Kuropiĭ T S, Utegenov R B, Khelimskiĭ D A, Badoian A G, Éraliev T K, Krest'ianinov O V

机构信息

Department of Endovascular Diagnosis and Treatment, National Medical Research Centre named after Academician E.N. Meshalkin under the RF Ministry of Public Health, Novosibirsk, Russia.

出版信息

Angiol Sosud Khir. 2021;27(3):46-52. doi: 10.33529/ANGIO2021319.

Abstract

Interventions on bifurcation lesions of the coronary bed are one of the most complicated tasks of interventional cardiology. Recent trends are toward active study of using drug-eluting balloons for interventions in this type of lesions. Using such technique makes it possible to minimize the risks associated with implantation of stents in sites of coronary artery bifurcations with good angiographic results. This article is a review of the literature data concerning the use of drug-coated balloons in interventions on bifurcation lesions of the coronary bed, discussing peculiarities of the balloon catheter design, dynamics of delivery of an antiproliferative drug to the vascular wall. This is followed by considering the experience with using innovative sirolimus-coated balloon catheters, as well as future perspectives of these devices for interventions in coronary artery bifurcation lesions.

摘要

冠状动脉床分叉病变的介入治疗是介入心脏病学中最复杂的任务之一。最近的趋势是积极研究使用药物洗脱球囊对这类病变进行介入治疗。使用这种技术可以将冠状动脉分叉部位植入支架相关的风险降至最低,并获得良好的血管造影结果。本文综述了有关药物涂层球囊用于冠状动脉床分叉病变介入治疗的文献数据,讨论了球囊导管设计的特点、抗增殖药物向血管壁输送的动力学。随后考虑了使用创新的西罗莫司涂层球囊导管的经验,以及这些设备用于冠状动脉分叉病变介入治疗的未来前景。

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