轮状病毒疫苗试验在孟加拉国际腹泻病研究中心（icddr,b）和未来在孟加拉国使用该疫苗。
Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh.
机构信息
International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
International Vaccine Institute (IVI), Seoul, Republic of Korea.
出版信息
J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S801-S804. doi: 10.1093/infdis/jiab442.
Abstract
Safe and effective rotavirus vaccines (RVs) are needed to reduce the enormous public health burden of rotavirus illness in developing countries. Vaccination is critical for effective control of rotavirus infection since it cannot be prevented with improvements in water and sanitation. The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has completed several groundbreaking RV trials (Phase I-Phase IV). The safety, immunogenicity, efficacy, and effectiveness of different RVs were evaluated among both urban and rural populations. In this study, we present the results, policy implications, and lessons learned for successful implementation of these trials as well as future directions for rotavirus vaccination in Bangladesh.
摘要
需要安全有效的轮状病毒疫苗（RV）来减轻发展中国家轮状病毒病带来的巨大公共卫生负担。由于轮状病毒感染无法通过改善水和卫生条件来预防，因此疫苗接种对于有效控制轮状病毒感染至关重要。孟加拉国际腹泻病研究中心（icddr,b）已经完成了几项具有开创性的 RV 试验（I 期-IV 期）。在城市和农村人群中评估了不同 RV 的安全性、免疫原性、疗效和效果。在这项研究中，我们介绍了这些试验成功实施的结果、政策影响和经验教训，以及孟加拉国未来轮状病毒疫苗接种的方向。
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