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Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh.轮状病毒疫苗试验在孟加拉国际腹泻病研究中心（icddr,b）和未来在孟加拉国使用该疫苗。
J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S801-S804. doi: 10.1093/infdis/jiab442.
2
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J Infect Dis. 2018 Apr 11;217(9):1399-1407. doi: 10.1093/infdis/jiy054.
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Methodology and lessons-learned from the efficacy clinical trial of the pentavalent rotavirus vaccine in Bangladesh.从戊型轮状病毒疫苗在孟加拉国的疗效临床试验中学到的方法和经验。
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Clin Infect Dis. 2018 Jul 2;67(2):186-192. doi: 10.1093/cid/ciy076.

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Nutritional Profiles and Zinc Supplementation among Children with Diarrhea in Bangladesh.孟加拉国腹泻儿童的营养状况和补锌情况。
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本文引用的文献

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Impact of vaccination on the risk factors for acute rotavirus diarrhea: An analysis of the data of a cluster randomized trial conducted in a rural area of Bangladesh.疫苗接种对急性轮状病毒腹泻危险因素的影响：孟加拉国农村地区一项整群随机试验数据分析。
Vaccine. 2020 Feb 24;38(9):2190-2197. doi: 10.1016/j.vaccine.2020.01.041. Epub 2020 Jan 23.
2
A randomized Phase I/II study to evaluate safety and reactogenicity of a heat-stable rotavirus vaccine in healthy adults followed by evaluation of the safety, reactogenicity, and immunogenicity in infants.一项评估热稳定轮状病毒疫苗在健康成人中的安全性和反应原性的随机I/II期研究，随后评估该疫苗在婴儿中的安全性、反应原性和免疫原性。
Hum Vaccin Immunother. 2020 Mar 3;16(3):693-702. doi: 10.1080/21645515.2019.1664239. Epub 2019 Oct 29.
3
Economic costs of hospitalized diarrheal disease in Bangladesh: a societal perspective.孟加拉国住院腹泻病的经济成本：社会视角
Glob Health Res Policy. 2018 Jan 5;3:1. doi: 10.1186/s41256-017-0056-5. eCollection 2018.
4
Impact and cost-effectiveness of rotavirus vaccination in Bangladesh.孟加拉国轮状病毒疫苗接种的影响及成本效益
Vaccine. 2017 Jul 13;35(32):3982-3987. doi: 10.1016/j.vaccine.2017.05.087. Epub 2017 Jun 13.
5
Effectiveness of a live oral human rotavirus vaccine after programmatic introduction in Bangladesh: A cluster-randomized trial.孟加拉国引入口服轮状病毒活疫苗后的效果：一项整群随机试验。
PLoS Med. 2017 Apr 18;14(4):e1002282. doi: 10.1371/journal.pmed.1002282. eCollection 2017 Apr.
6
Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial.亚洲发展中国家婴幼儿五价轮状病毒疫苗对严重轮状病毒胃肠炎的效力：一项随机、双盲、安慰剂对照试验。
Lancet. 2010 Aug 21;376(9741):615-23. doi: 10.1016/S0140-6736(10)60755-6. Epub 2010 Aug 6.
7
Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age.在孟加拉国婴儿12周和16周龄时按两剂次程序成功联合接种人轮状病毒疫苗和口服脊髓灰质炎病毒疫苗。
Vaccine. 2009 Feb 25;27(9):1333-9. doi: 10.1016/j.vaccine.2008.12.059. Epub 2009 Jan 20.
8
Safety and immunogenicity of tetravalent rhesus-based rotavirus vaccine in Bangladesh.基于恒河猴的四价轮状病毒疫苗在孟加拉国的安全性和免疫原性。
Pediatr Infect Dis J. 2001 Dec;20(12):1136-43. doi: 10.1097/00006454-200112000-00009.

轮状病毒疫苗试验在孟加拉国际腹泻病研究中心（icddr,b）和未来在孟加拉国使用该疫苗。

Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Future Use of the Vaccine in Bangladesh.

机构信息

International Centre for Diarrhoeal Disease Research  Bangladesh, Dhaka, Bangladesh.

International Vaccine Institute (IVI), Seoul, Republic of Korea.

出版信息

J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S801-S804. doi: 10.1093/infdis/jiab442.

DOI:10.1093/infdis/jiab442
PMID:34528671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8687083/
Abstract

Safe and effective rotavirus vaccines (RVs) are needed to reduce the enormous public health burden of rotavirus illness in developing countries. Vaccination is critical for effective control of rotavirus infection since it cannot be prevented with improvements in water and sanitation. The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has completed several groundbreaking RV trials (Phase I-Phase IV). The safety, immunogenicity, efficacy, and effectiveness of different RVs were evaluated among both urban and rural populations. In this study, we present the results, policy implications, and lessons learned for successful implementation of these trials as well as future directions for rotavirus vaccination in Bangladesh.

摘要

需要安全有效的轮状病毒疫苗（RV）来减轻发展中国家轮状病毒病带来的巨大公共卫生负担。由于轮状病毒感染无法通过改善水和卫生条件来预防，因此疫苗接种对于有效控制轮状病毒感染至关重要。孟加拉国际腹泻病研究中心（icddr,b）已经完成了几项具有开创性的 RV 试验（I 期-IV 期）。在城市和农村人群中评估了不同 RV 的安全性、免疫原性、疗效和效果。在这项研究中，我们介绍了这些试验成功实施的结果、政策影响和经验教训，以及孟加拉国未来轮状病毒疫苗接种的方向。