Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Centre for Health Evaluation & Outcome Sciences, Vancouver, BC, Canada.
Pain Manag. 2022 Apr;12(3):337-346. doi: 10.2217/pmt-2021-0064. Epub 2021 Sep 16.
Ketamine is an anesthetic agent that at lower doses can be a potent analgesic. There has been an interest in the use of low dose ketamine in treatment of chronic pain syndromes. We report the results of a retrospective observational study for patients diagnosed with a chronic noncancer pain syndrome receiving a 2-week continuous subanesthetic IV ketamine infusion. We conclude that a 10-14 days of subanesthetic ketamine infusion in chronic patients results in clinically significant lowering of patients' numerical pain score. Further studies looking at subanesthetic ketamine infusion in a prospective trial of multi-day IV ketamine infusion in chronic refractory chronic neuropathic pain are needed to further assess the efficacy of ketamine.
氯胺酮是一种麻醉剂，低剂量时可以作为一种有效的镇痛剂。在慢性疼痛综合征的治疗中，低剂量氯胺酮的应用引起了人们的兴趣。我们报告了一项回顾性观察研究的结果，该研究针对的是诊断为慢性非癌性疼痛综合征的患者，他们接受了为期 2 周的连续亚麻醉静脉输注氯胺酮。我们的结论是，慢性患者接受 10-14 天的亚麻醉氯胺酮输注会导致患者数字疼痛评分显著降低。需要进一步研究亚麻醉氯胺酮输注，以在慢性难治性慢性神经性疼痛的前瞻性试验中评估多日静脉输注氯胺酮的疗效。
