Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
Chem Commun (Camb). 2021 Sep 16;57(74):9398-9401. doi: 10.1039/d1cc03494d.
A tumor cell membrane-camouflaged therapeutic system was fabricated to eliminate tumors by embedding apyrase and glucose oxidase (GOx) into zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for tumor-targeted metabolic therapy. Experimental results demonstrated that these functional nanoparticles could disturb the energy supply of tumor cells by depleting ATP and glucose and efficiently induce tumor cell death.
一种肿瘤细胞膜伪装治疗系统被构建出来，通过将胞嘧啶核苷三磷酸酶（apyrase）和葡萄糖氧化酶（GOx）嵌入沸石咪唑酯骨架-8（ZIF-8）纳米颗粒中，用于肿瘤靶向代谢治疗。实验结果表明，这些功能纳米颗粒可以通过消耗 ATP 和葡萄糖来干扰肿瘤细胞的能量供应，从而有效地诱导肿瘤细胞死亡。
