一种嵌入生物酶的肿瘤细胞仿生纳米平台，用于增强代谢治疗。
A tumor-cell biomimetic nanoplatform embedding biological enzymes for enhanced metabolic therapy.
机构信息
Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
出版信息
Chem Commun (Camb). 2021 Sep 16;57(74):9398-9401. doi: 10.1039/d1cc03494d.
A tumor cell membrane-camouflaged therapeutic system was fabricated to eliminate tumors by embedding apyrase and glucose oxidase (GOx) into zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for tumor-targeted metabolic therapy. Experimental results demonstrated that these functional nanoparticles could disturb the energy supply of tumor cells by depleting ATP and glucose and efficiently induce tumor cell death.
一种肿瘤细胞膜伪装治疗系统被构建出来，通过将胞嘧啶核苷三磷酸酶（apyrase）和葡萄糖氧化酶（GOx）嵌入沸石咪唑酯骨架-8（ZIF-8）纳米颗粒中，用于肿瘤靶向代谢治疗。实验结果表明，这些功能纳米颗粒可以通过消耗 ATP 和葡萄糖来干扰肿瘤细胞的能量供应，从而有效地诱导肿瘤细胞死亡。
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