Department of Mathematics, National Institute of Technology Durgapur Durgapur-713209, India.
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Langmuir. 2021 Sep 28;37(38):11316-11329. doi: 10.1021/acs.langmuir.1c01875. Epub 2021 Sep 16.
The biomimetic core-shell nanoparticles coated with membranes of various biological cells have attracted significant research interest, because of their extensive applications in targeted drug delivery systems. The cell membrane consists of a lipid bilayer, which can be regarded as a two-dimensional oriented viscous liquid with low dielectric permittivity, compared to a bulk aqueous medium. Such a liquid layer comprised of cell membrane may bear additional mobile charges, because of the presence of free lipid molecules or charged surfactant molecules, which further results in nonzero charge along the surface of the peripheral layer. In this article, we present an analytical theory for electrophoresis of such cell membrane coated functionalized nanoparticles in the extent of electrolyte solution, considering the combined effects of finite ion size and of ion partitioning. Going beyond the Debye-Huckel approximations, we propose an analytical theory for Donnan potential and electrophoretic mobility. The derived expressions are applicable for moderate to highly charged undertaken core-shell particles when the thickness of the peripheral liquid layer greatly exceeds the electric double layer thickness. The impact of pertinent parameters on the electrophoretic response of such a particle is further discussed.
包覆有各种生物细胞膜的仿生核壳纳米粒子由于其在靶向药物传递系统中的广泛应用而引起了极大的研究兴趣。细胞膜由脂质双层组成，与体相水介质相比，它可以被视为具有低介电常数的二维各向异性粘性液体。由于存在游离脂质分子或带电表面活性剂分子，这种由细胞膜组成的液层可能带有额外的可移动电荷，这进一步导致在周边层的表面上存在非零电荷。在本文中，我们提出了一种在电解质溶液范围内研究这种细胞膜包覆功能化纳米粒子电泳的分析理论，考虑了有限离子大小和离子分配的综合影响。超越德拜-休克尔近似，我们提出了一种关于唐南势和电泳迁移率的分析理论。当外围液体层的厚度大大超过双电层厚度时，所得到的表达式适用于中等至高度带电的核壳粒子。进一步讨论了相关参数对这种粒子电泳响应的影响。
