Pawlik W W, Gustaw P, Czarnobilski K, Konturek S J
Institute of Physiology, School of Medicine, Cracow.
Acta Physiol Pol. 1987 Sep-Oct;38(5):418-24.
Effects of pentagastrin on systemic circulation were studied in anesthetized cats. Systemic arterial, central venous and portal pressure were monitored with electromanometers and blood flow through the superior mesenteric artery, common carotid artery, femoral artery and ascending aorta were measured with an electromagnetic blood flow meter. Pentagastrin injected intravenously at a doses of 2.0, 4.0 and 8.0 micrograms/kg induced a dose-dependent fall in arterial pressure, heart rate and cardiac output, increased mesenteric blood flow, decreased common carotid artery blood flow, did not change femoral artery blood flow and slightly rose central venous pressure. Atropine blocked observed effects. After repeated injections of the peptide, tachyphylaxis quickly developed. The obtained results indicate that pentagastrin influences general hemodynamics probably via interaction with cholinergic receptors.
在麻醉猫身上研究了五肽胃泌素对体循环的影响。使用电子血压计监测体动脉、中心静脉和门静脉压力，并用电磁血流计测量通过肠系膜上动脉、颈总动脉、股动脉和升主动脉的血流量。以2.0、4.0和8.0微克/千克的剂量静脉注射五肽胃泌素，可引起动脉压、心率和心输出量呈剂量依赖性下降，肠系膜血流量增加，颈总动脉血流量减少，股动脉血流量不变，中心静脉压略有升高。阿托品可阻断观察到的效应。重复注射该肽后，快速出现快速耐受性。所得结果表明，五肽胃泌素可能通过与胆碱能受体相互作用影响全身血液动力学。
