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[中国三级医院非瓣膜性心房颤动住院患者血栓栓塞风险评估的现状]

[Current status of thromboembolism risk assessment in patients hospitalized with non-valvular atrial fibrillation in tertiary hospitals in China].

作者信息

Yang N, Zhao D, Liu J, Hao Y C, Zeng Y Y, Hu D Q, Sun Z Q, Yang Y Q, Li H W, Liu T X, Wang Y, Liu J

机构信息

Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing100029, China.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 2021 Sep 24;49(9):856-865. doi: 10.3760/cma.j.cn112148-20201231-01028.

DOI:10.3760/cma.j.cn112148-20201231-01028
PMID:34530592
Abstract

To analyze the current status, trend and predictors of thromboembolism risk assessment in patients hospitalized with non-valvular atrial fibrillation (NVAF) in tertiary hospitals in China. The study was based on data from the Improving Care for Cardiovascular disease in China (CCC)-Atrial Fibrillation (AF) project. About 10% of the tertiary hospitals in each geographic-economic stratum were recruited. Participating hospitals reported the first 10 to 20 patients with a discharge diagnosis of atrial fibrillation monthly. From February 2015 to December 2019, a total of 49 104 NVAF patients from 151 tertiary hospitals in 30 provinces, municipalities and autonomous regions were enrolled. Clinical data of the patients was collected. The proportion of NVAF patients receiving thromboembolism risk assessment, variations in the proportion between different hospitals, the time trend of the application of thromboembolism risk assessment, and the predictors of the application of thromboembolism risk assessment were analyzed. The age of the NVAF patients was (68.7±12.1) years, 27 709 patients (56.4%) were male. Only 17 251 patients (35.1%) received thromboembolism risk assessment. The proportion varied substantially between hospitals with the lowest value of 0 and the highest value of 100%. Among the hospitals, which enrolled more than 30 patients, no patients received thromboembolism risk assessment in 18.4% (26/141) of the hospitals, more than 50% of the patients received thromboembolism risk assessment in 21.3% (30/141) of the hospitals, and all the patients received thromboembolism risk assessment in only 1 hospital. The proportion of NVAF patients receiving thromboembolism risk assessment was 16.2% (220/1 362) in the first quarter of 2015, and significantly increased to 67.1% (1 054/1 572) in the last quarter of 2019 (<0.001). Patients' characteristics were associated with the application of thromboembolism risk assessment. The odds of receiving thromboembolism risk assessment was lower in male patients compared to female patients(=0.94,95% 0.89-0.99), lower in patients with acute coronary syndrome or other cardiovascular diseases compared to those with AF as the primary admission reason (=0.59, 95% 0.55-0.63, =0.52, 95% 0.45-0.61, respectively), and lower in patients with paroxysmal, persistent and long-standing/permanent AF compared to those with first detected AF (=0.62, 95% 0.57-0.67, =0.72, 95% 0.66-0.79, =0.57, 95% 0.52-0.64, respectively). The odds was higher in patients with a history of hypertension, heart failure, stroke/TIA, and previous anticoagulant therapy compared to those without the above conditions (=1.17, 95% 1.11-1.23, =1.18, 95% 1.07-1.30, =1.17, 95% 1.08-1.27, =1.28, 95% 1.19-1.37, respectively) ( all<0.05). Thromboembolism risk assessment was underused in patients hospitalized with NVAF in tertiary hospitals in China, and there were substantial variations between hospitals in the application of thromboembolism risk assessment. The application of thromboembolism risk assessment in tertiary hospitals has been improved in recent years, but there is still plenty of room for future improvement. Patients' characteristics could affect the application of thromboembolism risk assessment in China.

摘要

分析中国三级医院非瓣膜性心房颤动(NVAF)住院患者血栓栓塞风险评估的现状、趋势及预测因素。本研究基于中国心血管疾病医疗质量改善(CCC)-心房颤动(AF)项目的数据。在每个地理经济分层中,约10%的三级医院被纳入研究。参与研究的医院每月上报前10至20例出院诊断为心房颤动的患者。2015年2月至2019年12月,共纳入来自30个省、直辖市和自治区151家三级医院的49104例NVAF患者。收集患者的临床资料。分析NVAF患者接受血栓栓塞风险评估的比例、不同医院之间比例的差异、血栓栓塞风险评估应用的时间趋势以及血栓栓塞风险评估应用的预测因素。NVAF患者的年龄为(68.7±12.1)岁,27709例患者(56.4%)为男性。仅17251例患者(35.1%)接受了血栓栓塞风险评估。不同医院之间的比例差异很大,最低值为0,最高值为100%。在纳入患者超过30例的医院中,18.4%(26/141)的医院没有患者接受血栓栓塞风险评估,21.3%(30/141)的医院超过50%的患者接受了血栓栓塞风险评估,只有1家医院所有患者都接受了血栓栓塞风险评估。2015年第一季度,接受血栓栓塞风险评估的NVAF患者比例为16.2%(220/1362),到2019年最后一个季度显著增至67.1%(1054/1572)(<0.001)。患者特征与血栓栓塞风险评估的应用有关。男性患者接受血栓栓塞风险评估的几率低于女性患者(比值比=0.94,95%置信区间0.89 - 0.99),以急性冠状动脉综合征或其他心血管疾病为入院主要原因的患者低于以AF为入院主要原因的患者(分别为比值比=0.59,95%置信区间0.55 - 0.63;比值比=0.52,95%置信区间0.45 - 0.61),阵发性、持续性和长期/永久性AF患者低于首次检测到AF的患者(分别为比值比=0.62,95%置信区间0.57 - 0.67;比值比=0.72,95%置信区间0.66 - 0.79;比值比=0.57,95%置信区间0.52 - 0.64)。有高血压、心力衰竭、卒中/TIA病史以及既往接受过抗凝治疗的患者接受血栓栓塞风险评估的几率高于无上述情况的患者(分别为比值比=1.17,95%置信区间1.11 - 1.23;比值比=1.18,95%置信区间1.07 - 1.30;比值比=1.17,95%置信区间1.08 - 1.27;比值比=1.28,95%置信区间1.19 - 1.37)(均P<0.05)。中国三级医院NVAF住院患者的血栓栓塞风险评估使用不足,不同医院在血栓栓塞风险评估的应用上存在很大差异。近年来三级医院血栓栓塞风险评估的应用有所改善,但未来仍有很大的改进空间。患者特征会影响中国血栓栓塞风险评估的应用。

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