Institute for Environmental Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
Biomarkers. 2021 Dec;26(8):691-702. doi: 10.1080/1354750X.2021.1981448. Epub 2021 Oct 13.
Understanding interactions of smoking topography with biomarkers of exposure to tobacco is essential for accurate smoking risk assessments.
In this study, the smoking topography and the levels of tobacco smoke exposure urinary biomarkers of a sample of active Korean smokers were quantified and measured. The results were used to investigate the effect of daily activities and smoking time on the smoking topography. Moreover, correlations between the smoking topography parameters and biomarkers were assessed.
No significant effect of either the daily activities or time on the smoking topography of the subjects were observed. Synchronic correlations of the cigarette consumption per day (CPD) and the average flow per puff with both urinary cotinine and trans-3'-hydroxycotinine were significant. For the urinary nicotine metabolites, the peak levels appeared when the CPD was over 19 cigarettes per day and the average puff velocity was between 35 and 45 ml/s. Nevertheless, when the average flow was over 60 ml/s, the levels of cotinine and trans-3'-hydroxycotinine significantly dropped.
The findings of this study may be beneficial for further smoking risk assessments with contributions of both the smoking topography and biomarkers to provide current smokers with applicable cession programs.Clinical significanceSmoking habits and levels of urinary biomarkers of Korean smokers are investigated.People with a higher dependency on nicotine smoke cigarettes with slower puffs.Effects of daily activities or time on smoking topography were not significant.Correlations between smoking topography and urinary biomarkers were significant.Peak biomarker levels were observed under certain smoking topography conditions.
了解吸烟特征与烟草暴露生物标志物的相互作用对于准确评估吸烟风险至关重要。
本研究对一组活跃的韩国吸烟者的吸烟特征和烟草烟雾暴露生物标志物的水平进行了量化和测量。结果用于研究日常活动和吸烟时间对吸烟特征的影响。此外，评估了吸烟特征参数与生物标志物之间的相关性。
未观察到日常活动或时间对受试者吸烟特征的显著影响。每天吸烟量（CPD）和每口气流的平均流量与尿中可替宁和反式-3'-羟基可替宁均呈同步相关。对于尿中尼古丁代谢物，当 CPD 超过 19 支/天且平均吸气流速在 35 至 45ml/s 之间时，出现峰值水平。然而，当平均流量超过 60ml/s 时，可替宁和反式-3'-羟基可替宁的水平显著下降。
本研究的结果可能有助于进一步进行吸烟风险评估，将吸烟特征和生物标志物的贡献结合起来，为当前吸烟者提供可行的戒烟计划。
研究了韩国吸烟者的吸烟习惯和尿液生物标志物水平。对尼古丁烟雾依赖性较高的人吸烟时吸气流速较慢。日常活动或时间对吸烟特征的影响不显著。吸烟特征与尿液生物标志物之间存在显著相关性。在某些吸烟特征条件下观察到生物标志物的峰值水平。
