Yan Jia, Qiu Panda, Zhang Xinyu, Zhang Yuanyuan, Mi Linjing, Peng Cheng, Pan Xiaoqi, Peng Fu
Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery, System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced, Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P. R. China.
Am J Chin Med. 2021;49(7):1623-1643. doi: 10.1142/S0192415X21500750. Epub 2021 Sep 16.
Biochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. The publications collected from PubMed, ScienceDirect, and Wiley databases were summarized for the last 10 years. Then, the potential therapeutic use of BCA on the treatment of various diseases was discussed according to its pharmacological properties, namely, anticancer, anti-inflammatory, anti-bacterial, anti-diabetic, and anti-obesity effects as well as neuroprotective, hepatoprotective, cardioprotective, and osteoprotective effects. BCA might mainly regulate the MAPK, PI3K, NRF2, and NF-kB pathways, respectively, to exert its bioactive effects. However, the limited definitive targets, poor biological availability, and insufficient safety evaluation might block the clinical application of BCA. This review may provide new insights for the development of BCA in the application of related diseases.
生物chanin A（BCA）是一种膳食异黄酮，从豆科植物以及许多其他中药材的叶和茎中分离得到。最近的研究结果表明，BCA是一种具有多种生物活性作用的有前景的候选药物。为了评估BCA临床应用的可能性，本综述试图对BCA的药理作用进行全面总结。对过去10年从PubMed、ScienceDirect和Wiley数据库收集的出版物进行了总结。然后，根据其药理特性，即抗癌、抗炎、抗菌、抗糖尿病和抗肥胖作用以及神经保护、肝脏保护、心脏保护和骨保护作用，讨论了BCA在治疗各种疾病方面的潜在治疗用途。BCA可能主要分别调节MAPK、PI3K、NRF2和NF-κB信号通路，以发挥其生物活性作用。然而，有限的明确靶点、较差的生物利用度和不足的安全性评估可能会阻碍BCA的临床应用。本综述可能为BCA在相关疾病应用中的开发提供新的见解。
