颈动脉体去神经的自发性高血压大鼠对急性缺氧的血压、心率及动脉血气反应
Blood pressure, heart rate and arterial blood gas reactions to acute hypoxia in carotid body denervated spontaneously hypertensive rats.
作者信息
Huckstorf C, Behm R, Habeck J O, Rückborn K, Franz U
机构信息
Institute of Physiology, Wilhelm-Pieck University, GDR, Rostock.
出版信息
Biomed Biochim Acta. 1987;46(12):925-31.
The role of the peripheral arterial chemoreceptors in the reflex control of respiration and the cardiovascular systems was studied in spontaneously hypertensive rats (SHR). In carotid body denervated and in sham-operated control rats mean arterial blood pressure, heart rate, respiratory rate and arterial blood gases were measured under normoxic conditions and in acute normobaric hypoxia. Under normoxia the carotid body denervated SHR differ from the sham-operated ones only in significantly lowered arterial pO2 and pH and in significantly increased pCO2 values. The carotid body denervated SHR react to acute hypoxia with a significantly smaller increase in respiratory rate, a more pronounced fall in the arterial pO2 and a greater decrease in mean arterial blood pressure than the sham-operated control rats. Our results suggest that carotid body chemoreceptors in SHR are of great importance in regulating respiration but of secondary consequence regarding the reflex control of the cardiovascular system.
在自发性高血压大鼠（SHR）中研究了外周动脉化学感受器在呼吸和心血管系统反射性控制中的作用。在颈动脉体去神经支配的大鼠和假手术对照大鼠中，于常氧条件下以及急性常压缺氧时测量平均动脉血压、心率、呼吸频率和动脉血气。在常氧条件下，颈动脉体去神经支配的SHR与假手术大鼠的区别仅在于动脉血氧分压和pH值显著降低，以及二氧化碳分压值显著升高。与假手术对照大鼠相比，颈动脉体去神经支配的SHR对急性缺氧的反应是呼吸频率增加明显较小、动脉血氧分压下降更显著以及平均动脉血压下降幅度更大。我们的结果表明，SHR中的颈动脉体化学感受器在调节呼吸方面非常重要，但在心血管系统的反射性控制方面则是次要的。
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