Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Department of Biostatistics, School of Public Health, Shandong University, Jinan, Shandong, China.
Nutr Metab Cardiovasc Dis. 2021 Oct 28;31(11):3103-3110. doi: 10.1016/j.numecd.2021.07.009. Epub 2021 Jul 29.
Triglyceride-glucose index (TyG) and high-sensitivity C-reactive protein (hsCRP) have been shown to play important roles in the pathophysiological mechanisms of atherogenesis. However, the cumulative value of TyG and hsCRP in identifying asymptomatic intracranial arterial stenosis (aICAS), as well as its severity and numerical burden, is uncertain. This study seeks to fill this knowledge gap.
This study included 1938 participants aged ≥40 years who were free of stroke or transient ischemic attack. All participants were classified into four groups based on the participants' TyG and hsCRP levels, including low-TyG and low-hsCRP, low-TyG and high-hsCRP, high-TyG and low-hsCRP, and high-TyG and high-hsCRP groups. The presence of aICAS was screened via transcranial Doppler ultrasound and confirmed by magnetic resonance angiography. The TyG was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. We used multinomial logistic regression analysis to investigate the cumulative value of TyG and hsCRP on identifying the severity of aICAS or its numerical burden. After adjustment for conventional confounders, isolated high-hsCRP, isolated high-TyG, and high-TyG combined with high-hsCRP were independently associated with moderate-to-severe aICAS. Compared with the low-TyG and low-hsCRP group, participants with high-TyG and high-hsCRP had a 2.6 times higher odds ratio (OR) of having a single moderate-to-severe aICAS and a 3.3 times higher OR of having multiple moderate-to-severe aICASs.
The cumulative value of TyG and hsCRP may better identify moderate-to-severe aICAS as well as its numerical burden.
甘油三酯-葡萄糖指数（TyG）和高敏 C 反应蛋白（hsCRP）在动脉粥样硬化发病机制的病理生理机制中发挥着重要作用。然而，TyG 和 hsCRP 的累积值在识别无症状颅内动脉狭窄（aICAS）及其严重程度和数量负担方面的作用尚不确定。本研究旨在填补这一知识空白。
本研究纳入了 1938 名年龄≥40 岁且无卒中或短暂性脑缺血发作的参与者。所有参与者均根据参与者的 TyG 和 hsCRP 水平分为四组，包括低 TyG 和低 hsCRP、低 TyG 和高 hsCRP、高 TyG 和低 hsCRP 以及高 TyG 和高 hsCRP 组。通过经颅多普勒超声筛查 aICAS 的存在，并通过磁共振血管造影进行确认。TyG 的计算方法为 ln[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]。我们使用多变量逻辑回归分析来探讨 TyG 和 hsCRP 的累积值对识别 aICAS 严重程度或其数量负担的作用。在调整了常规混杂因素后，孤立的 hsCRP 升高、孤立的 TyG 升高以及 TyG 升高合并 hsCRP 升高与中重度 aICAS 独立相关。与低 TyG 和低 hsCRP 组相比，高 TyG 和高 hsCRP 组发生单个中重度 aICAS 的比值比（OR）为 2.6 倍，发生多个中重度 aICAS 的 OR 为 3.3 倍。
TyG 和 hsCRP 的累积值可能更好地识别中重度 aICAS 及其数量负担。
