胸腔脓胸兔模型中瓜蒌水提物的纤维蛋白溶解作用研究。

Study of Aqueous Ecballium Elaterium as Fibrinolytic in The Rabbit Model of Intrapleural Empyema.

机构信息

Harran University, Medical School, Thoracic Surgery, Sanliurfa, Dicle University, Medical School, Diyarbakir, Turkey.

Thoracic Surgery, Harran University, Medical School, Thoracic Surgery, Sanliurfa, Dicle University, Medical School, Diyarbakir, Turkey.

出版信息

Niger J Clin Pract. 2021 Sep;24(9):1326-1331. doi: 10.4103/njcp.njcp_360_20.

DOI:10.4103/njcp.njcp_360_20

PMID:34531345

Abstract

AIMS

We aimed to investigate of intrapleural use of ecballium elaterium (EE) in a rabbit model empyema.

METHODS

An empyema was induced in 21 rabbits after inoculation of Staphylococcus aureus. Glucose levels, pH, lactate dehydrogenase levels, and amounts of pleural drainage were evaluated in addition to pleural and empyema scores. The rabbits were divided into three groups, each 7, the isotonic solution, the streptokinase, and the ecballium group.

RESULTS

At autopsy, there was no difference in pH, glucose, and LDH levels in three groups. The mean pleural drainage was greater in the ecballium group. A significant difference was detected between groups in terms of drainage amounts and pleural and empyema scores (P < 0.05). A significant difference in pleural and empyema scores was detected in the ecballium and streptokinase groups (P < 0.05). EE group had significant differences in drainage amounts and plural and empyema scores regard to the control group (P < 0.05). No significance was found between streptokinase and EE groups.

CONCLUSION

We conclude that intrapleural use of EE is at least as effective as streptokinase for the treatment of empyema.

摘要

目的

我们旨在研究瑞香狼毒（EE）在兔脓胸模型中的胸膜内应用。

方法

在接种金黄色葡萄球菌后，21 只兔子诱导脓胸。除了胸腔和脓胸评分外，还评估了葡萄糖水平、pH 值、乳酸脱氢酶水平和胸腔引流量。将兔子分为三组，每组 7 只，分别为等渗溶液组、链激酶组和瑞香狼毒组。

结果

尸检时，三组间 pH 值、葡萄糖和 LDH 水平无差异。瑞香狼毒组胸腔引流量较大。三组间引流量和胸腔及脓胸评分差异有统计学意义（P<0.05）。瑞香狼毒和链激酶组胸腔和脓胸评分差异有统计学意义（P<0.05）。与对照组相比，瑞香狼毒组在引流量和胸腔及脓胸评分方面差异有统计学意义（P<0.05）。链激酶组与瑞香狼毒组之间无显著性差异。