Harran University, Medical School, Thoracic Surgery, Sanliurfa, Dicle University, Medical School, Diyarbakir, Turkey.
Thoracic Surgery, Harran University, Medical School, Thoracic Surgery, Sanliurfa, Dicle University, Medical School, Diyarbakir, Turkey.
Niger J Clin Pract. 2021 Sep;24(9):1326-1331. doi: 10.4103/njcp.njcp_360_20.
We aimed to investigate of intrapleural use of ecballium elaterium (EE) in a rabbit model empyema.
An empyema was induced in 21 rabbits after inoculation of Staphylococcus aureus. Glucose levels, pH, lactate dehydrogenase levels, and amounts of pleural drainage were evaluated in addition to pleural and empyema scores. The rabbits were divided into three groups, each 7, the isotonic solution, the streptokinase, and the ecballium group.
At autopsy, there was no difference in pH, glucose, and LDH levels in three groups. The mean pleural drainage was greater in the ecballium group. A significant difference was detected between groups in terms of drainage amounts and pleural and empyema scores (P < 0.05). A significant difference in pleural and empyema scores was detected in the ecballium and streptokinase groups (P < 0.05). EE group had significant differences in drainage amounts and plural and empyema scores regard to the control group (P < 0.05). No significance was found between streptokinase and EE groups.
We conclude that intrapleural use of EE is at least as effective as streptokinase for the treatment of empyema.
我们旨在研究瑞香狼毒（EE）在兔脓胸模型中的胸膜内应用。
在接种金黄色葡萄球菌后，21 只兔子诱导脓胸。除了胸腔和脓胸评分外，还评估了葡萄糖水平、pH 值、乳酸脱氢酶水平和胸腔引流量。将兔子分为三组，每组 7 只，分别为等渗溶液组、链激酶组和瑞香狼毒组。
尸检时，三组间 pH 值、葡萄糖和 LDH 水平无差异。瑞香狼毒组胸腔引流量较大。三组间引流量和胸腔及脓胸评分差异有统计学意义（P<0.05）。瑞香狼毒和链激酶组胸腔和脓胸评分差异有统计学意义（P<0.05）。与对照组相比，瑞香狼毒组在引流量和胸腔及脓胸评分方面差异有统计学意义（P<0.05）。链激酶组与瑞香狼毒组之间无显著性差异。
我们得出结论，瑞香狼毒胸膜内应用至少与链激酶一样有效治疗脓胸。
