Lee Sang-Soo, Kim Yong-An, Eun Bokkee, Yoo Jayeon, Kim Eun-Mi, Nam Myoung Soo, Kim Kee K
Department of Biochemistry Chungnam National University Daejeon Korea.
Core Laboratory for Convergent Translational Research Korea University College of Medicine Seoul Korea.
Food Sci Nutr. 2021 Jul 14;9(9):5083-5091. doi: 10.1002/fsn3.2466. eCollection 2021 Sep.
Sarcopenia is a disease characterized by the loss of muscle mass and function that occurs mainly in older adults. The present study was designed to investigate the hypothesis that water extract of (WELC) would improve muscle function and promote myogenesis for sarcopenia. We investigated the effect of water extracts of . on muscular endurance function and myogenesis to examine its efficacy in sarcopenia. Intake of WELC-containing cheese enhanced the muscular endurance function of mice in treadmill endurance tests. In addition, the cross-sectional areas of muscle fibers in the gastrocnemius muscle of . -fed mice were greater than that of control mice. Furthermore, WELC and its key component marker substance betaine promoted myogenesis of myoblasts by increasing the expression of the myogenic protein myosin heavy chain 3 (Myh3) and myotube formation. Taken together, our results suggest that . may potentially be useful in the development of preventive and therapeutic agents for sarcopenia, as well as in providing basic knowledge on myogenesis and muscular functions.
肌肉减少症是一种主要发生在老年人身上的以肌肉质量和功能丧失为特征的疾病。本研究旨在调查[具体物质]水提取物（WELC）可改善肌肉减少症的肌肉功能并促进肌生成这一假设。我们研究了[具体物质]水提取物对肌肉耐力功能和肌生成的影响，以检验其对肌肉减少症的疗效。摄入含WELC的奶酪可增强小鼠在跑步机耐力测试中的肌肉耐力功能。此外，喂食[具体物质]的小鼠腓肠肌中肌纤维的横截面积大于对照小鼠。此外，WELC及其关键成分标记物质甜菜碱通过增加肌源性蛋白肌球蛋白重链3（Myh3）的表达和肌管形成来促进成肌细胞的肌生成。综上所述，我们的结果表明，[具体物质]可能在开发肌肉减少症的预防和治疗药物方面具有潜在用途，同时也能为肌生成和肌肉功能提供基础知识。
