Sorraya Nasim, Farrokhzad Amirhosein, Hassani Bahar, Talebi Shokoofeh
Department of Community Nutrition School of Nutrition and Food Science Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran.
Department of Orthopedics Isfahan University of Medical Sciences Isfahan Iran.
Food Sci Nutr. 2021 Jul 23;9(9):5312-5323. doi: 10.1002/fsn3.2478. eCollection 2021 Sep.
We aimed to perform a meta-analysis, using prospective cohort studies, to test the association between serum potassium and all-cause mortality among chronic kidney diseases (CKD) patients. A systematic search was performed using PubMed-MEDLINE and Scopus, up to July 2020. Prospective cohort studies which reported risk estimates of all-cause mortality in CKD patients with different serum potassium levels were included in the present meta-analysis. Thirteen studies were included in the analysis. A nonlinear dose-response meta-analysis suggested that there is a J-shaped association between serum potassium levels and the risk of all-cause mortality, with a nadir at serum potassium of 4.5 mmol/L. Subgroup analyses indicated that the strength and shape of the association between serum potassium and all-cause mortality may be influenced by age. Our meta-analysis provides supportive evidence that there is a J-shape association between serum potassium and all-cause mortality among CKD patients.
我们旨在通过前瞻性队列研究进行一项荟萃分析，以检验慢性肾脏病（CKD）患者血清钾与全因死亡率之间的关联。截至2020年7月，我们使用PubMed-MEDLINE和Scopus进行了系统检索。本荟萃分析纳入了报告不同血清钾水平的CKD患者全因死亡率风险估计值的前瞻性队列研究。分析纳入了13项研究。非线性剂量反应荟萃分析表明，血清钾水平与全因死亡率风险之间存在J形关联，血清钾水平为4.5 mmol/L时出现最低点。亚组分析表明，血清钾与全因死亡率之间关联的强度和形状可能受年龄影响。我们的荟萃分析提供了支持性证据，表明CKD患者血清钾与全因死亡率之间存在J形关联。
