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胰岛素瘤伴神经症状的糖耐量受损

Impaired glucose tolerance with neurological manifestations in insulinoma.

作者信息

Villanueva-Rodríguez Luis Geraldine, Reza-Albarrán Alfredo Adolfo, Cárdenas Enrique, Ángeles Arturo, Lester Jacobo

机构信息

Internal Medicine/Endocrinology Hospital Angeles Lomas Huixquilucan Mexico.

Endocrinology Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" Tlalpan Mexico.

出版信息

Clin Case Rep. 2021 Sep 12;9(9):e04532. doi: 10.1002/ccr3.4532. eCollection 2021 Sep.

DOI:10.1002/ccr3.4532
PMID:34532041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8435222/
Abstract

Insulinoma may have an atypical presentation and it should be suspected in patients with neurological manifestations in spite of an atypical insulin and proinsulin levels associated with hypoglycemia. Fast test is an important tool to reach the diagnosis.

摘要

胰岛素瘤可能有非典型表现，尽管低血糖相关的胰岛素和胰岛素原水平不典型，但对于有神经学表现的患者仍应怀疑该病。快速检测是做出诊断的重要手段。

相似文献

1
Impaired glucose tolerance with neurological manifestations in insulinoma.胰岛素瘤伴神经症状的糖耐量受损
Clin Case Rep. 2021 Sep 12;9(9):e04532. doi: 10.1002/ccr3.4532. eCollection 2021 Sep.
2
Hypoglycemia in response to glucose and glucagon in insulinoma patients with a negative prolonged fast: functional and morphological properties.延长禁食试验结果为阴性的胰岛素瘤患者对葡萄糖和胰高血糖素的低血糖反应：功能和形态学特征
J Endocrinol Invest. 2004 Oct;27(9):832-8. doi: 10.1007/BF03346277.
3
Forty-eight-hour fast: the diagnostic test for insulinoma.48小时禁食：胰岛素瘤的诊断试验。
J Clin Endocrinol Metab. 2000 Sep;85(9):3222-6. doi: 10.1210/jcem.85.9.6807.
4
Diagnosis and minimally invasive resection of an insulinoma: report of an unusual case and review of the literature.胰岛素瘤的诊断与微创切除：1例罕见病例报告及文献复习
Am Surg. 2007 May;73(5):520-4.
5
Insulinoma with hyperproinsulinemia during hypoglycemia and loss of expression of vacuolar-type H(+)-ATPase (V-ATPase) in the tumor tissue.低血糖期间伴有高胰岛素原血症的胰岛素瘤以及肿瘤组织中液泡型H(+)-ATP酶（V-ATP酶）表达缺失。
Int J Pancreatol. 1999 Feb;25(1):11-6. doi: 10.1385/IJGC:25:1:11.
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[Hypoglycemia: clarification and etiology].[低血糖症：阐释与病因]
Schweiz Med Wochenschr. 1980 Mar 29;110(13):495-8.
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Diagnostic accuracy of an "amended" insulin-glucose ratio for the biochemical diagnosis of insulinomas.改良胰岛素-葡萄糖比值对胰岛素瘤生化诊断的准确性。
Ann Intern Med. 2012 Dec 4;157(11):767-75. doi: 10.7326/0003-4819-157-11-201212040-00004.
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Concurrent insulinoma and impaired glucose tolerance suspected as owing to obesity.同时怀疑存在胰岛素瘤及因肥胖导致的糖耐量受损。
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Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma.采用免疫化学发光分析法检测胰岛素原用于胰岛素瘤的诊断。
J Clin Endocrinol Metab. 1994 May;78(5):1048-51. doi: 10.1210/jcem.78.5.8175958.
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A Clinicopathological Study of Malignant Insulinoma in a Contemporary Series.当代系列恶性胰岛素瘤的临床病理研究
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本文引用的文献

1
2. Classification and Diagnosis of Diabetes: .2. 糖尿病的分类和诊断： 。
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27. doi: 10.2337/dc18-S002.
2
Insulinoma with a History of Epilepsy: Still a Possible Misleading Factor in the Early Diagnosis of Insulinoma.有癫痫病史的胰岛素瘤：仍是胰岛素瘤早期诊断中可能存在的误导因素。
Intern Med. 2017 Dec 1;56(23):3199-3204. doi: 10.2169/internalmedicine.8932-17. Epub 2017 Oct 11.
3
Diagnosis of insulinoma using the ratios of serum concentrations of insulin and C-peptide to glucose during a 5-hour oral glucose tolerance test.
在5小时口服葡萄糖耐量试验期间，利用胰岛素和C肽的血清浓度与葡萄糖的比值诊断胰岛素瘤。
Endocr J. 2017 Jan 30;64(1):49-57. doi: 10.1507/endocrj.EJ16-0292. Epub 2016 Oct 1.
4
Clinical efficacy of dual-phase scanning using (68)Ga-DOTATOC-PET/CT in the detection of neuroendocrine tumours.使用（68）Ga-DOTATOC-PET/CT双期扫描检测神经内分泌肿瘤的临床疗效
Clin Radiol. 2016 Oct;71(10):1069.e1-1069.e5. doi: 10.1016/j.crad.2016.04.017. Epub 2016 May 19.
5
ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors.《欧洲神经内分泌肿瘤学会功能性胰腺神经内分泌肿瘤和非功能性胰腺神经内分泌肿瘤患者管理共识指南更新》
Neuroendocrinology. 2016;103(2):153-71. doi: 10.1159/000443171. Epub 2016 Jan 5.
6
Concurrent insulinoma and impaired glucose tolerance suspected as owing to obesity.同时怀疑存在胰岛素瘤及因肥胖导致的糖耐量受损。
BMJ Case Rep. 2016 Jan 4;2016:bcr2015213793. doi: 10.1136/bcr-2015-213793.
7
Insulinoma diagnosed as drug-refractory epilepsy in an adolescent boy: a case report.青少年男性胰岛素瘤误诊为难治性癫痫1例报告
Rom J Morphol Embryol. 2013;54(4):1147-51.
8
The role of proinsulin and insulin in the diagnosis of insulinoma: a critical evaluation of the Endocrine Society clinical practice guideline.胰岛素原和胰岛素在胰岛素瘤诊断中的作用：对内分泌学会临床实践指南的批判性评估。
J Clin Endocrinol Metab. 2013 Dec;98(12):4752-8. doi: 10.1210/jc.2013-2182. Epub 2013 Sep 30.
9
Glucose-responsive insulinoma in a patient with postprandial hypoglycemia in the morning.一名早晨出现餐后低血糖的患者患有葡萄糖反应性胰岛素瘤。
Intern Med. 2010;49(19):2123-7. doi: 10.2169/internalmedicine.49.3854. Epub 2010 Oct 1.
10
Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline.成人低血糖症的评估与管理：内分泌学会临床实践指南
J Clin Endocrinol Metab. 2009 Mar;94(3):709-28. doi: 10.1210/jc.2008-1410. Epub 2008 Dec 16.