Sahashi Yu, Sahashi Miwako, Hikasa Yoshiaki
Sahashi Veterinary Hospital, 23-10 Kitabatake, Ueno, Inagawa, Kawabe-gun, Hyogo 666-0244, Japan.
Laboratory of Veterinary Internal Medicine, Department of Clinical Veterinary Science, Joint Graduate School of Veterinary Sciences, Tottori University, 4-101 Koyama Minami, Tottori 680-8553, Japan.
Case Rep Vet Med. 2021 Sep 3;2021:6054125. doi: 10.1155/2021/6054125. eCollection 2021.
Pravastatin (PS) has been found to increase left ventricle (LV) expansion capacity and decrease LV constriction and left atrial pressure in healthy dogs. To date, there are no available reports on the effects of PS in dogs with hypercholesterolemia with chronic heart failure (CHF). This case report demonstrates a successful long-term treatment plan using PS in a dog suffering from mitral insufficiency with hyperlipidemia. A 12-year-old, castrated male Chihuahua dog had mitral insufficiency with hyperlipidemia. The dog presented with symptoms of chronic coughing. PS was orally administered (1 mg/kg, SID) in addition to general treatment for mitral insufficiency. The follow-up period was 375 days. PS administration decreased the heart rate (HR), vertebral heart size (VHS), and N-terminal probrain natriuretic peptide (NT-proBNP) concentration of the dog. In addition, PS administration also improved chronic cardiac failure induced by mitral insufficiency and hyperlipidemia. This report suggests that PS can be useful as an adjunctive therapeutic for dogs with hypercholesterolemia with mitral insufficiency.
已发现普伐他汀（PS）可增加健康犬的左心室（LV）扩张能力，降低左心室收缩和左心房压力。迄今为止，尚无关于PS对患有慢性心力衰竭（CHF）的高胆固醇血症犬影响的报道。本病例报告展示了使用PS对一只患有二尖瓣关闭不全伴高脂血症的犬进行成功的长期治疗方案。一只12岁的去势雄性吉娃娃犬患有二尖瓣关闭不全伴高脂血症。该犬出现慢性咳嗽症状。除了对二尖瓣关闭不全进行常规治疗外，还口服给予PS（1毫克/千克，每日一次）。随访期为375天。给予PS降低了犬的心率（HR）、心脏椎体大小（VHS）和N末端脑钠肽前体（NT-proBNP）浓度。此外，给予PS还改善了由二尖瓣关闭不全和高脂血症引起的慢性心力衰竭。本报告表明，PS可作为患有二尖瓣关闭不全的高胆固醇血症犬的辅助治疗药物。
