Scarim Cauê Benito, de Farias Renan Lira, Chiba Diego Eidy, Chin Chung Man
Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, 14800-903, Brazil.
Lapdesf - Laboratory of Research and Development of Drugs, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.
Curr Med Chem. 2022;29(13):2334-2381. doi: 10.2174/0929867328666210917114912.
Scaffolds of metal-based compounds can act as pharmacophore groups in several ligands to treat various diseases, including tropical infectious diseases (TID). In this review article, we investigate the contribution of these moieties to medicinal inorganic chemistry in the last seven years against TID, including American trypanosomiasis (Chagas disease), human African trypanosomiasis (HAT, sleeping sickness), leishmania, and malaria. The most potent metal-based complexes are displayed and highlighted in figures, tables and graphics; according to their pharmacological activities (IC > 10μM) against Trypanosomatids and Plasmodium spp parasites. We highlight the current progresses and viewpoints of these metal-based complexes, with a specific focus on drug discovery.
金属基化合物支架可作为多种配体中的药效基团，用于治疗包括热带传染病（TID）在内的各种疾病。在这篇综述文章中，我们研究了这些部分在过去七年中对治疗TID的药用无机化学的贡献，包括美洲锥虫病（恰加斯病）、人类非洲锥虫病（昏睡病）、利什曼病和疟疾。最有效的金属基配合物在图表和图形中展示并突出显示；根据它们对锥虫和疟原虫寄生虫的药理活性（IC>10μM）。我们重点介绍了这些金属基配合物的当前进展和观点，特别关注药物发现。
