Division of Molecular Medicine, Boston Children's Hospital, 3 Blackfan Street, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, United States.
Division of Molecular Medicine, Boston Children's Hospital, 3 Blackfan Street, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, United States.
Curr Opin Virol. 2021 Oct;50:173-182. doi: 10.1016/j.coviro.2021.08.010. Epub 2021 Sep 8.
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep understanding of the structure-function relationships of viral proteins and relevant host factors. The trimeric spike (S) protein of the virus decorates the viral surface and is an important target for development of diagnostics, therapeutics and vaccines. Rapid progress in the structural biology of SARS-CoV-2 S protein has been made since the early stage of the pandemic, advancing our knowledge on the viral entry process considerably. In this review, we summarize our latest understanding of the structure of the SARS-CoV-2 S protein and discuss the implications for vaccines and therapeutics.
新型冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2 型（SARS-CoV-2）引起的一种疾病，导致数百万人失去生命，并在全球范围内造成破坏性的社会经济后果。该疾病急需干预策略来控制危机，而满足这些需求需要深入了解病毒蛋白和相关宿主因素的结构-功能关系。病毒的三聚体刺突（S）蛋白装饰着病毒表面，是开发诊断、治疗和疫苗的重要目标。自大流行早期以来，SARS-CoV-2 S 蛋白的结构生物学取得了快速进展，大大提高了我们对病毒进入过程的认识。在这篇综述中，我们总结了对 SARS-CoV-2 S 蛋白结构的最新理解，并讨论了其对疫苗和治疗的影响。
