Stanhope R, Hindmarsh P, Pringle P J, Holownia P, Honour J, Brook C G
Endocrine Unit, Middlesex Hospital, London, UK.
Pediatrician. 1987;14(3):183-8.
We describe the treatment of 3 boys, mean age 14.9 years (range 13.8-16.1 years) with constitutional delay of growth and puberty using oxandrolone in two dose regimens, 2.5 or 1.25 mg/day for 3 months. Treatment induced an increase in mean height velocity from 5.1 to 8.5 cm/year; this was sustained at 8.8 cm/year in the period following treatment. Growth hormone (GH), luteinising hormone and testosterone secretion were assessed by overnight or 24-hour venous sampling at 15-min intervals before, during treatment and after cessation of treatment. A computer programme was used to analyse GH secretory dynamics. The 3 boys had a mean sustained increase in total GH secretion of 190%. The increase in GH secretion was associated with an increase in amplitude of GH pulses rather than an alteration in pulse frequency.
我们描述了对3名平均年龄14.9岁（范围13.8 - 16.1岁）的体质性生长和青春期延迟男孩使用氧雄龙进行治疗的情况，采用两种剂量方案，即2.5毫克/天或1.25毫克/天，持续3个月。治疗使平均身高增长速度从每年5.1厘米增加到8.5厘米；在治疗后的时期内，这一速度维持在每年8.8厘米。在治疗前、治疗期间和治疗停止后，通过每隔15分钟进行一次过夜或24小时静脉采血来评估生长激素（GH）、促黄体生成素和睾酮的分泌情况。使用计算机程序分析GH分泌动态。这3名男孩的总GH分泌平均持续增加了190%。GH分泌的增加与GH脉冲幅度的增加有关，而不是脉冲频率的改变。
