Link K, Blizzard R M, Evans W S, Kaiser D L, Parker M W, Rogol A D
J Clin Endocrinol Metab. 1986 Jan;62(1):159-64. doi: 10.1210/jcem-62-1-159.
Oxandrolone (Ox) and testosterone (T) are used as growth-promoting agents in the therapy of boys with constitutional delay of growth and adolescence. Although the mechanism of action of these androgens is not known, it is recognized that T enhances GH release during GH stimulation tests. We studied the effects of T and Ox on the mean concentration of GH, the pattern of GH secretion, and somatomedin-C (SmC) concentrations in boys with short stature and/or delayed sexual development to determine whether their growth-promoting effects might be mediated through endogenous GH release. Ten boys received Ox (0.1 mg/kg . day, orally) for 65 +/- 5 days (mean +/- SD), and five boys received T propionate (7.5 mg, im, for 7 days), followed by T enanthate (100 mg, im, monthly for 3 months). Serum GH was measured in samples obtained at 20-min intervals for 24 h before and 65 +/- 5 days (mean +/- SD) after the initiation of therapy. SmC levels were measured twice during the same 24-h period before and 65 +/- 5 days (mean +/- SD) after initiation of therapy. In the boys treated with T, there were significant increases in the mean concentration of GH (mean increase, 4.3-fold; range, 2-12), in the number of GH pulses 10 ng/ml or greater [1.6 +/- 2.0 vs. 4.8 +/- 1.5/24 h (mean +/- SD)], and in the SmC levels [0.82 +/- 0.46 vs. 2.3 +/- 0.4 mu/ml (mean +/- SD)]. There were, however, no significant changes in the boys treated with Ox. Both Ox and T significantly improved the growth rates; however, T increased the growth rate by 0.95 +/- 0.24 (mean +/- SD) cm/months, and Ox increased the growth rate by 0.24 +/- 0.26 (mean +/- SD) cm/month. These results indicate that T, but not Ox, at the doses tested increases GH secretion in boys with short stature and/or delayed sexual development. This increase in GH secretion may contribute to the increased growth rate in males at puberty.
氧雄龙（Ox）和睾酮（T）在治疗体质性生长和青春期延迟的男孩时被用作促生长剂。尽管这些雄激素的作用机制尚不清楚，但人们认识到T在生长激素刺激试验期间可增强生长激素的释放。我们研究了T和Ox对身材矮小和/或性发育延迟男孩的生长激素平均浓度、生长激素分泌模式以及胰岛素样生长因子-C（SmC）浓度的影响，以确定它们的促生长作用是否可能通过内源性生长激素释放来介导。10名男孩口服Ox（0.1mg/kg·天），持续65±5天（平均值±标准差），5名男孩接受丙酸睾酮（7.5mg，肌肉注射，共7天），随后接受庚酸睾酮（100mg，肌肉注射，每月1次，共3个月）。在治疗开始前24小时和治疗开始后65±5天（平均值±标准差），每隔20分钟采集一次血清样本，测量生长激素水平。在相同的24小时期间，治疗开始前和治疗开始后65±5天（平均值±标准差）测量两次SmC水平。在接受T治疗的男孩中，生长激素平均浓度显著增加（平均增加4.3倍；范围为2 - 12），生长激素脉冲数≥10ng/ml的情况显著增加[1.6±2.0对4.8±1.5/24小时（平均值±标准差）]，SmC水平也显著增加[0.82±0.46对2.3±0.4μg/ml（平均值±标准差）]。然而，接受Ox治疗的男孩没有显著变化。Ox和T均显著提高了生长速率；然而，T使生长速率提高了0.95±0.24（平均值±标准差）cm/月，Ox使生长速率提高了0.24±0.26（平均值±标准差）cm/月。这些结果表明，在所测试的剂量下，T而非Ox可增加身材矮小和/或性发育延迟男孩的生长激素分泌。生长激素分泌的这种增加可能有助于男性青春期生长速率的提高。
