Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, Osaka, 545-8585, Japan.
Department of Premier Preventive Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Clin J Gastroenterol. 2021 Dec;14(6):1607-1611. doi: 10.1007/s12328-021-01520-5. Epub 2021 Sep 18.
We experienced six cases with eosinophilic esophagitis (EoE). They complained of dysphagia, heartburn, or retrosternal discomfort. Endoscopy revealed typical findings of EoE and biopsy examination showed significant eosinophil infiltration in the esophageal epithelium. They received sublingual immunotherapy (SLIT) for allergic rhinitis. Discontinuation or spit method during SLIT resulted in improvement of symptoms, and endoscopic and histological remission. Previously six cases with SLIT-induced EoE has been reported. Our case series suggest that SLIT is clearly associated with the development of EoE by entering of aeroallergens from the luminal side of the esophagus and spit method during SLIT might be one of the therapeutic options for SLIT-induced EoE.
我们共遇到了 6 例嗜酸性食管炎（EoE）患者。他们主诉吞咽困难、烧心或胸骨后不适。内镜检查显示出 EoE 的典型表现，活检显示食管上皮有明显的嗜酸性粒细胞浸润。他们因过敏性鼻炎接受舌下免疫治疗（SLIT）。SLIT 期间中断或吐出药物导致症状改善，内镜和组织学缓解。此前已经报道过 6 例 SLIT 诱导的 EoE。我们的病例系列表明，SLIT 通过从食管腔侧进入过敏原以及 SLIT 期间的吐出药物的方法，与 EoE 的发生明显相关，而 SLIT 期间吐出药物可能是 SLIT 诱导的 EoE 的治疗选择之一。
