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在内镜下经鼓室软骨鼓膜成形术中切除或保留穿孔边缘不影响手术成功率。

Excising or preserving perforation margins in endoscopic transtympanic cartilage myringoplasty does not affect surgical success.

作者信息

Lou Zhengcai, Lou Zihan, Jin Kangfeng, Sun Junzhi, Chen Zhengnong

机构信息

Department of Otorhinolaryngology, Yiwu central Hospital, Yiwu, China.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

出版信息

Clin Otolaryngol. 2022 Jan;47(1):94-99. doi: 10.1111/coa.13863. Epub 2021 Oct 15.

Abstract

OBJECTIVE

To compare the outcome of endoscopic transtympanic cartilage myringoplasty with and without removal of perforation edges for repairing chronic perforations with mucosal chronic otitis media (COM).

STUDY DESIGN

Quasi-randomised clinical trial.

SETTING

Tertiary referral centre.

MATERIALS AND METHODS

Patients with chronic perforations and mucosal COM undergoing endoscopic transtympanic cartilage myringoplasty were allocated to a control group for whom the perforation edges were preserved (n = 40) and an intervention group for whom the edges were removed (n = 39). Mean operation time, graft success rate, mean scores of graft neovascularisation and epithelialisation, and hearing were compared between the groups at 4 weeks and/or 6 months postoperatively.

RESULTS

Graft success rate was 95% (38/40) in the control group and 97% (38/39) in the intervention group at 6 months postoperatively; the difference was not significant. Mean graft neovascularisation scores 4 weeks postoperatively were 2.52 ± 0.59 in the control group and 2.58 ± 0.55 in the intervention group; the difference was not significant. Mean graft epithelisation scores 4 weeks postoperatively were 1.48 ± 0.57 in the control group and 1.68 ± 0.51 in the intervention group; the difference was not significant and remained nonsignificant 6 months postoperatively (2.5 ± 0.55 vs. 2.76 ± 0.36). Audiological outcomes at 6 months did not differ between the groups.

CONCLUSION

Endoscopic, transtympanic cartilage underlay myringoplasty with preservation of the perforation margins did not affect graft neovascularisation, epithelialisation or success. Longer-term outcomes and risk of cholesteatoma require further study.

摘要

目的

比较在内镜下经鼓室软骨鼓膜成形术中,保留与不保留穿孔边缘修复慢性穿孔伴黏膜性慢性中耳炎(COM)的效果。

研究设计

半随机临床试验。

研究地点

三级转诊中心。

材料与方法

将接受内镜下经鼓室软骨鼓膜成形术的慢性穿孔和黏膜性COM患者分为对照组(保留穿孔边缘,n = 40)和干预组(去除穿孔边缘,n = 39)。比较两组术后4周和/或6个月时的平均手术时间、移植物成功率、移植物新生血管形成和上皮化的平均评分以及听力。

结果

术后6个月时,对照组的移植物成功率为95%(38/40),干预组为97%(38/39);差异无统计学意义。术后4周时,对照组移植物新生血管形成的平均评分为2.52±0.59,干预组为2.58±0.55;差异无统计学意义。术后4周时,对照组移植物上皮化的平均评分为1.48±0.57,干预组为1.68±0.51;差异无统计学意义,术后6个月时仍无统计学意义(2.5±0.55 vs. 2.76±0.36)。两组在6个月时的听力学结果无差异。

结论

在内镜下经鼓室软骨下鼓膜成形术中保留穿孔边缘不影响移植物的新生血管形成、上皮化或成功率。胆脂瘤的长期结局和风险需要进一步研究。

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