卡路里限制对年轻和老年大鼠的神经免疫系统有不同的调节作用。
Calorie restriction modulates neuro-immune system differently in young and aged rats.
作者信息
Chakraborty Apala, Banerjee Soumyabrata, Mukherjee Biswajit, Poddar Mrinal K, Ali Nahid
机构信息
Department of Pharmaceutical Technology, Jadavpur University, 188, Raja S.C Mallick Road, Kolkata 700032, India.
Department of Pharmaceutical Technology, Jadavpur University, 188, Raja S.C Mallick Road, Kolkata 700032, India; Department of Psychology, Neuroscience Program, Field Neurosciences Institute Research Laboratory for Restorative Neurology, Central Michigan University, Mount Pleasant, MI 48859, USA.
出版信息
Int Immunopharmacol. 2021 Nov;100:108141. doi: 10.1016/j.intimp.2021.108141. Epub 2021 Sep 15.
Aging weakens and deregulates the immune system and plays an impact on the central nervous system (CNS). A crosstalk in between the CNS-mediated immune system and the body's overall innate immunity is often found to increase and subsequently accelerate neurodegeneration and behavioural impairment during aging. Dietary calorie restriction (CR) is found to be a beneficial non-invasive anti-aging therapy as it shows rejuvenation of stress response, brain functions and behaviour during aging. The present investigation deals with the consequence of CR diet supplementation for two different duration (one and two consecutive months) on aging-related alteration of the immune response in male albino Wistar rats at the level of (a) lymphocyte viability, proliferation, cytotoxicity, and DNA fragmentation in blood, spleen, and thymus and (b) cytokines (IL-6, IL-10, and TNF-α) in blood, spleen, thymus and different brain-regions to understand the effect of CR diet on neuroimmune system. The results depict that CR diet consumption for consecutive one and two months by the aged (18 and 24 months) rats significantly attenuated the aging-related (a) decrease of blood, splenic and thymic lymphocyte viability, proliferative activity, cytotoxicity, and IL-10 level and (b) increase of (i) blood, splenic and thymic DNA fragmentation and (ii) IL-6 and TNF-α level in those tissues and also in different brain regions. Unlike older rats, in young (4 months) rats, the consumption of CR diet under similar conditions affected those above-mentioned immune parameters reversibly and adversely. This study concludes that (a) aging significantly (p < 0.01) deregulates the above-mentioned immune parameters, (b) consecutive consumption of CR diet for one and two months is (i) beneficial (p < 0.05) to the aging-related immune system [lymphocyte viability, lymphocyte proliferation, cytotoxicity, pro (IL-6 and TNF-α)- and anti (IL-10)-inflammatory cytokines], but (ii) adverse (p < 0.05) to the immune parameters of the young rats, and (c) consumption of CR diet for consecutive two months is more potent (p < 0.05) than that due to one month.
衰老会削弱并失调免疫系统，还会对中枢神经系统（CNS）产生影响。人们经常发现，中枢神经系统介导的免疫系统与身体整体固有免疫之间的相互作用会在衰老过程中增强，进而加速神经退行性变和行为障碍。饮食热量限制（CR）被认为是一种有益的非侵入性抗衰老疗法，因为它能使衰老过程中的应激反应、脑功能和行为恢复活力。本研究探讨了连续两个月（一个月和两个月）补充CR饮食对雄性白化Wistar大鼠免疫反应的衰老相关改变的影响，具体涉及以下方面：（a）血液、脾脏和胸腺中淋巴细胞的活力、增殖、细胞毒性和DNA片段化；（b）血液、脾脏、胸腺和不同脑区中的细胞因子（IL-6、IL-10和TNF-α），以了解CR饮食对神经免疫系统的影响。结果表明，18个月和24个月大的大鼠连续食用CR饮食一个月和两个月后，显著减轻了与衰老相关的：（a）血液、脾脏和胸腺淋巴细胞活力、增殖活性、细胞毒性和IL-10水平的降低；（b）（i）血液、脾脏和胸腺DNA片段化以及（ii）这些组织和不同脑区中IL-6和TNF-α水平的升高。与老年大鼠不同，4个月大的年轻大鼠在类似条件下食用CR饮食会对上述免疫参数产生可逆的不利影响。本研究得出以下结论：（a）衰老会显著（p < 0.01）失调上述免疫参数；（b）连续食用CR饮食一个月和两个月：（i）对与衰老相关的免疫系统[淋巴细胞活力、淋巴细胞增殖、细胞毒性、促炎（IL-6和TNF-α）和抗炎（IL-10）细胞因子]有益（p < 0.05），但（ii）对年轻大鼠的免疫参数不利（p < 0.05）；（c）连续两个月食用CR饮食比一个月更有效（p < 0.05）。
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