Centre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London, United Kingdom.
Centre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London, United Kingdom.
Curr Opin Microbiol. 2021 Dec;64:19-26. doi: 10.1016/j.mib.2021.08.008. Epub 2021 Sep 16.
Citrobacter rodentium, a natural mouse pathogen which colonises the colon of immuno-competent mice, provides a robust model for interrogating host-pathogen-microbiota interactions in vivo. This model has been key to providing new insights into local host responses to enteric infection, including changes in intestinal epithelial cell immunometabolism and mucosal immunity. C. rodentium injects 31 bacterial effectors into epithelial cells via a type III secretion system (T3SS). Recently, these effectors were shown to be able to form multiple intracellular subnetworks which can withstand significant contractions whilst maintaining virulence. Here we highlight recent advances in understanding gut mucosal responses to infection and effector biology, as well as potential uses for artificial intelligence (AI) in understanding infectious disease and speculate on the role of T3SS effector networks in host adaption.
柠檬酸杆菌，一种天然的鼠病原体，定植于免疫功能正常的老鼠的结肠，为体内研究宿主-病原体-微生物群相互作用提供了一个强大的模型。该模型对于深入了解肠道感染引起的局部宿主反应至关重要，包括肠道上皮细胞免疫代谢和黏膜免疫的变化。柠檬酸杆菌通过 III 型分泌系统（T3SS）将 31 种细菌效应物注入上皮细胞。最近，这些效应物被证明能够形成多个能够在保持毒力的同时承受明显收缩的细胞内子网。在这里，我们重点介绍了对感染和效应物生物学的肠道黏膜反应的最新理解，以及人工智能（AI）在理解传染病方面的潜在用途，并推测 T3SS 效应物网络在宿主适应中的作用。
