Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):8345-8349. doi: 10.1080/14767058.2021.1974385. Epub 2021 Sep 19.
The aim of this study to describe the presentation of double inlet left ventricle (DILV) very early in prenatal life, to assess its prevalence and to portray the associated anomalies.
This was a retrospective study which included all the women who attended our clinic for early fetal screening sonography, between 2006 and 2020. Most of the screening was done at 14-16 weeks of gestation (except one high risk pregnancy, which was performed at nine gestational weeks), and included an anatomic fetal scan and Doppler imaging. The diagnosis of DILV was done based on sonographic features of abnormal four-chamber view. Complete fetal echocardiography was carried out to rule out additional heart malformations.
Out of 26,805 early prenatal transvaginal ultrasound screening examinations, 14 cases of DILV were diagnosed. The gestational age range of our DILV diagnosis was 9-16 gestational weeks. All pregnancies were terminated as per parental request. In five fetuses, a chromosomal analysis was performed, one had trisomy 21, and the rest fetuses had a normal karyotype. In two fetuses, an autopsy was performed and the diagnosis of DILV was confirmed in both.
Very early prenatal detection of DILV is possible and may have an implication in parent decision regarding their pregnancy future.
本研究旨在描述双入口左心室（DILV）在产前早期的表现，评估其发生率，并描述相关的畸形。
这是一项回顾性研究，纳入了 2006 年至 2020 年期间在我院接受早期胎儿筛查超声检查的所有女性。大多数筛查在妊娠 14-16 周进行（除了一个高危妊娠在妊娠 9 周进行），包括胎儿解剖超声检查和多普勒成像。DILV 的诊断基于异常四腔心切面的超声特征。进行完整的胎儿超声心动图检查以排除其他心脏畸形。
在 26805 例早期产前经阴道超声筛查检查中，诊断出 14 例 DILV。我们的 DILV 诊断的胎龄范围为 9-16 周。所有妊娠均根据父母的要求终止。在 5 例胎儿中进行了染色体分析，其中 1 例为 21 三体，其余胎儿核型正常。在 2 例胎儿中进行了尸检，均确诊为 DILV。
非常早期的产前 DILV 检测是可能的，这可能对父母关于其妊娠未来的决策产生影响。
