Temple University School of Podiatric Medicine, 148 N 8th Street, Philadelphia, PA 19107, USA.
Temple University School of Podiatric Medicine, 148 N 8th Street, Philadelphia, PA 19107, USA.
Clin Podiatr Med Surg. 2021 Oct;38(4):553-559. doi: 10.1016/j.cpm.2021.06.007.
Psoriasis is a common inflammatory disorder with potentially severe systemic and dermatologic consequences. As traditional treatments for this condition fail, biologics are emerging as the next promising therapy for moderate-to-severe cases, especially for the lower extremity. This review examines current research on monoclonal antibodies that target specific cytokines including interleukin-23 (IL-23), IL-12, tumor necrosis factor alpha, and IL-17 involved in pathologic inflammatory processes.
银屑病是一种常见的炎症性疾病，可能会导致严重的全身性和皮肤学后果。随着传统疗法对这种疾病的疗效下降，生物制剂作为一种有前途的治疗方法正在出现，尤其是针对中重度病例，特别是下肢。本文综述了目前针对特定细胞因子（包括白细胞介素-23（IL-23）、白细胞介素-12、肿瘤坏死因子α和白细胞介素-17）的单克隆抗体的研究进展，这些细胞因子参与病理性炎症过程。
