Temple University School of Podiatric Medicine, 148 North 8th Street, Philadelphia, PA 19107, USA.
Temple University School of Podiatric Medicine, 148 North 8th Street, Philadelphia, PA 19107, USA.
Clin Podiatr Med Surg. 2021 Oct;38(4):577-588. doi: 10.1016/j.cpm.2021.06.002.
Pyoderma gangrenosum (PG), which most frequently affects the lower extremity, is a complicated disease state that results from a combination of inflammation, neutrophilic invasion, and genetic predisposition. There may also be certain comorbidities involved or it may be idiopathic. The many variations of PG mean that it often presents and responds differently to various treatments based on the specific case. Overall, there have been improvements in understanding the disease; however, further research should focus on finding better ways to predict and prevent this rapidly progressive, painful disease.
坏疽性脓皮病（PG）最常影响下肢，是一种复杂的疾病状态，由炎症、中性粒细胞浸润和遗传易感性共同作用导致。也可能涉及某些合并症，或者可能是特发性的。PG 的多种变化意味着它通常根据具体情况表现不同，并对各种治疗有不同的反应。总的来说，人们对这种疾病的认识已经有所提高；然而，进一步的研究应该集中在寻找更好的方法来预测和预防这种快速进展、疼痛的疾病上。
