Yin Qianqian, Wang Longyun, Yu Haiyang, Chen Daquan, Zhu Wenwei, Sun Changgang
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Pharmacol. 2021 Sep 3;12:716672. doi: 10.3389/fphar.2021.716672. eCollection 2021.
The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immune mechanisms. Owing to the nature of this pathway and its potential cross-epitopes with multiple alternative pathways, the long-term efficacy of monotherapy-based adaptive targeting therapy is limited, and the majority of drugs targeting STATs are still in the preclinical phase. Meanwhile, curcumin, quercetin, and several kinds of plant polyphenol chemicals play roles in multiple sites of the JAK-STAT pathway to suppress abnormal activation. Polyphenol compounds have shown remarkable effects by acting on the JAK-STAT pathway in anti-inflammatory, antitumor, and cardiovascular disease control. This review summarizes the pharmacological effects of more than 20 kinds of phytochemicals on JAK-STAT signaling pathway according to the chemical structure of polyphenolic phytochemicals.
JAK-STAT信号通路是多种细胞因子信号转导的共同通路，与细胞增殖、凋亡、分化及炎症反应密切相关。它对于抑制炎症反应、启动固有免疫及协调适应性免疫机制至关重要。由于该通路的性质及其与多种替代通路潜在的交叉表位，基于单药的适应性靶向治疗的长期疗效有限，且大多数靶向STATs的药物仍处于临床前阶段。同时，姜黄素、槲皮素及几种植物多酚类化学物质在JAK-STAT通路的多个位点发挥作用以抑制异常激活。多酚类化合物通过作用于JAK-STAT通路在抗炎、抗肿瘤及心血管疾病控制方面已显示出显著效果。本综述根据多酚类植物化学物质的化学结构总结了20多种植物化学物质对JAK-STAT信号通路的药理作用。
