超声弹性成像评估精索静脉曲张相关性不育患者的睾丸生精功能

Evaluation of testicular spermatogenic function by ultrasound elastography in patients with varicocele-associated infertility.

作者信息

Li Keji, Liu Xin, Huang Yansong, Liu Xiaoli, Song Qian, Wang Ran

机构信息

Department of Urology Surgery, Affiliated Hospital of Hebei Engineering University Handan, Hebei, China.

Affiliated Hospital of Hebei Engineering University Handan, Hebei, China.

出版信息

Am J Transl Res. 2021 Aug 15;13(8):9136-9142. eCollection 2021.

PMID:34540028

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8430184/

Abstract

OBJECTIVE

To investigate the application of ultrasound elastography and color Doppler ultrasound in the evaluation of testicular spermatogenic function in patients with varicocele (VC) associated infertility.

METHODS

A total of 196 patients with VC-associated infertility treated in our hospital from January 2018 to January 2020 were included as the research subjects (VC group), and were classified into VC I group (66 cases), VC II group (60 cases), and VC III group (70 cases) according to the diameter of spermatic vein and the degree of reflux under ultrasound. 50 age-matched healthy subjects were included as the control group. Color ultrasound, ultrasound elastography and semen examination were performed on all patients.

RESULTS

Compared with control group, a lower left testicular volume in VC group and a lower right testicular volume in VC III group were observed, and the left testicular volume was inversely proportional to VC grade (all P<0.05). Statistically significant differences in sperm viability, sperm density, peak systolic velocity (PSV), and MEAN values were determined among the 4 groups by one-way ANOVA, and between two groups by the independent-samples t test (all P<0.05). Pearson correlation analysis revealed that sperm viability and sperm density had no correlation with PSV, resistive index (RI) and pulsatility index (PI) of the left testicular artery in VC group, but were negatively correlated with the MEAN values of the testis.

CONCLUSION

Ultrasound elastography can predict the semen quality in patients with VC-associated infertility.

CLINICAL TRIAL REGISTRATION

This study was registered with the registration No. ChiCTR2010189 (URL: http://www.chictr.org.cn/showproj.aspx?proj=2018XE057-3).

摘要

目的

探讨超声弹性成像及彩色多普勒超声在精索静脉曲张（VC）相关性不育患者睾丸生精功能评估中的应用。

方法

选取2018年1月至2020年1月在我院治疗的196例VC相关性不育患者作为研究对象（VC组），根据超声下精索静脉内径及反流程度分为VC I组（66例）、VC II组（60例）和VC III组（70例）。选取50例年龄匹配的健康受试者作为对照组。对所有患者进行彩色超声、超声弹性成像及精液检查。

结果

与对照组相比，VC组左侧睾丸体积较小，VC III组右侧睾丸体积较小，且左侧睾丸体积与VC分级呈负相关（均P<0.05）。采用单因素方差分析比较4组间精子活力、精子密度、收缩期峰值流速（PSV）及平均值差异有统计学意义，采用独立样本t检验比较两组间差异有统计学意义（均P<0.05）。Pearson相关分析显示，VC组精子活力和精子密度与左侧睾丸动脉PSV、阻力指数（RI）及搏动指数（PI）无关，但与睾丸平均值呈负相关。