Wang Rui, Su Qi, Yan Zhao-Peng
Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
World J Clin Cases. 2021 Aug 26;9(24):6964-6968. doi: 10.12998/wjcc.v9.i24.6964.
To discuss recurrence patterns and their significance in colorectal cancer. Preexisting medical hypotheses and the clinical phenomena of recurrence in colorectal cancer were evaluated and integrated. Colorectal cancer recurrence/metastasis consists of two types: recurrence from the activation of dormant cancer cells and recurrence from postoperative residual cancer cells. These two recurrences have their own unique mechanisms, biological behaviors, responses to therapy, and prognoses. For type 1 recurrences, surgical resection should be considered. Type 2 recurrences should be managed systematically in addition to surgical resection. The two types of colorectal cancer recurrence should be evaluated and managed separately.
讨论结直肠癌的复发模式及其意义。对现有的医学假说和结直肠癌复发的临床现象进行了评估和整合。结直肠癌复发/转移分为两种类型：休眠癌细胞激活导致的复发和术后残留癌细胞导致的复发。这两种复发具有各自独特的机制、生物学行为、对治疗的反应和预后。对于1型复发，应考虑手术切除。除手术切除外，2型复发应进行系统管理。两种类型的结直肠癌复发应分别进行评估和管理。
