Prolonged hyperadrenalinemia impairs exercise ability in rats.

This study was performed on rats with sustained (24 h) hyperadrenalinemia produced by sc implantation of retard adrenaline (A) tablets. Comparing with control, sham-operated animals, in A-treated rats duration of endurance exercise until exhaustion was shortened by approx. 40%. This was accompanied by: significant decreases of the pre-exercise muscle glycogen and creatine phosphate values in both "slow twitching" (soleus) and "fast twitching" (white portion of gastrocnemius) muscles, and of ATP content in soleus. Muscle lactate and pyruvate contents as well as blood glucose and FFA levels were elevated. After exercise muscle substrate and metabolite contents were similar in both groups in spite of the difference in exercise duration. It is concluded that prolonged hyperadrenalinemia diminishes the intramuscular energy substrate content, thereby reducing endurance capacity of rats.